FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161521034> ?p ?o ?g. }

• W2161521034 endingPage "13045" @default.
• W2161521034 startingPage "13037" @default.
• W2161521034 abstract "We explored the immunogenic properties of influenza A viruses with altered NS1 genes (NS1 mutant viruses). NS1 mutant viruses expressing NS1 proteins with an impaired RNA-binding function or insertion of a longer foreign sequence did not replicate in murine lungs but still were capable of inducing a Th1-type immune response resulting in significant titers of virus-specific serum and mucosal immunoglobulin G2 (IgG2) and IgA, but with lower titers of IgG1. In contrast, replicating viruses elicited high titers of serum and mucosal IgG1 but less serum IgA. Replication-deficient NS1 mutant viruses induced a rapid local release of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-6. Moreover, these viruses also elicited markedly higher levels of IFN-alpha/beta in serum than the wild-type virus. Comparable numbers of virus-specific primary CD8(+) T cells were determined in all of the groups of immunized mice. The most rapid onset of the recall CD8(+)-T-cell response upon the wild-type virus challenge was detected in mice primed with NS1 mutant viruses eliciting high levels of cytokines. It is noteworthy that there was one NS1 mutant virus encoding NS1 protein with a deletion of 40 amino acids predominantly in the RNA-binding domain that induced the highest levels of IFN-alpha/beta, IL-6 and IL-1beta after infection. Mice that were immunized with this virus were completely protected from the challenge infection. These findings indicate that a targeted modification of the RNA-binding domain of the NS1 protein is a valuable technique to generate replication-deficient, but immunogenic influenza virus vaccines." @default.
• W2161521034 created "2016-06-24" @default.
• W2161521034 creator A5006694993 @default.
• W2161521034 creator A5020100053 @default.
• W2161521034 creator A5022716555 @default.
• W2161521034 creator A5040263244 @default.
• W2161521034 creator A5049551961 @default.
• W2161521034 creator A5057067822 @default.
• W2161521034 creator A5057236500 @default.
• W2161521034 date "2004-12-01" @default.
• W2161521034 modified "2023-10-14" @default.
• W2161521034 title "Immunogenicity and Protection Efficacy of Replication-Deficient Influenza A Viruses with Altered NS1 Genes" @default.
• W2161521034 cites W1508567407 @default.
• W2161521034 cites W1531386680 @default.
• W2161521034 cites W1713603519 @default.
• W2161521034 cites W1783202259 @default.
• W2161521034 cites W1964804172 @default.
• W2161521034 cites W1966692566 @default.
• W2161521034 cites W1977457899 @default.
• W2161521034 cites W1981579957 @default.
• W2161521034 cites W1988161329 @default.
• W2161521034 cites W1992479402 @default.
• W2161521034 cites W1994710883 @default.
• W2161521034 cites W1998170251 @default.
• W2161521034 cites W1998437621 @default.
• W2161521034 cites W2001484558 @default.
• W2161521034 cites W2006003795 @default.
• W2161521034 cites W2011779891 @default.
• W2161521034 cites W2012362209 @default.
• W2161521034 cites W2013574284 @default.
• W2161521034 cites W2013704309 @default.
• W2161521034 cites W2021101853 @default.
• W2161521034 cites W2021106524 @default.
• W2161521034 cites W2025246568 @default.
• W2161521034 cites W2039782308 @default.
• W2161521034 cites W2043175663 @default.
• W2161521034 cites W2046182783 @default.
• W2161521034 cites W2051690374 @default.
• W2161521034 cites W2056732680 @default.
• W2161521034 cites W2067745123 @default.
• W2161521034 cites W2070343911 @default.
• W2161521034 cites W2072186294 @default.
• W2161521034 cites W2072383590 @default.
• W2161521034 cites W2074885782 @default.
• W2161521034 cites W2077332396 @default.
• W2161521034 cites W2077640158 @default.
• W2161521034 cites W2080921782 @default.
• W2161521034 cites W2091080683 @default.
• W2161521034 cites W2093102386 @default.
• W2161521034 cites W2098292021 @default.
• W2161521034 cites W2101179800 @default.
• W2161521034 cites W2102930999 @default.
• W2161521034 cites W2104444360 @default.
• W2161521034 cites W2112210686 @default.
• W2161521034 cites W2112901090 @default.
• W2161521034 cites W2131960074 @default.
• W2161521034 cites W2134261926 @default.
• W2161521034 cites W2143153889 @default.
• W2161521034 cites W2151778974 @default.
• W2161521034 cites W2164517987 @default.
• W2161521034 cites W2164953394 @default.
• W2161521034 cites W2169565071 @default.
• W2161521034 cites W2170408138 @default.
• W2161521034 cites W2232791900 @default.
• W2161521034 cites W2326305272 @default.
• W2161521034 cites W2341444760 @default.
• W2161521034 cites W2442595428 @default.
• W2161521034 cites W289288500 @default.
• W2161521034 cites W4251947800 @default.
• W2161521034 doi "https://doi.org/10.1128/jvi.78.23.13037-13045.2004" @default.
• W2161521034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/524997" @default.
• W2161521034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15542655" @default.
• W2161521034 hasPublicationYear "2004" @default.
• W2161521034 type Work @default.
• W2161521034 sameAs 2161521034 @default.
• W2161521034 citedByCount "119" @default.
• W2161521034 countsByYear W21615210342012 @default.
• W2161521034 countsByYear W21615210342013 @default.
• W2161521034 countsByYear W21615210342014 @default.
• W2161521034 countsByYear W21615210342015 @default.
• W2161521034 countsByYear W21615210342016 @default.
• W2161521034 countsByYear W21615210342017 @default.
• W2161521034 countsByYear W21615210342018 @default.
• W2161521034 countsByYear W21615210342019 @default.
• W2161521034 countsByYear W21615210342020 @default.
• W2161521034 countsByYear W21615210342021 @default.
• W2161521034 countsByYear W21615210342022 @default.
• W2161521034 countsByYear W21615210342023 @default.
• W2161521034 crossrefType "journal-article" @default.
• W2161521034 hasAuthorship W2161521034A5006694993 @default.
• W2161521034 hasAuthorship W2161521034A5020100053 @default.
• W2161521034 hasAuthorship W2161521034A5022716555 @default.
• W2161521034 hasAuthorship W2161521034A5040263244 @default.
• W2161521034 hasAuthorship W2161521034A5049551961 @default.
• W2161521034 hasAuthorship W2161521034A5057067822 @default.
• W2161521034 hasAuthorship W2161521034A5057236500 @default.
• W2161521034 hasBestOaLocation W21615210341 @default.
• W2161521034 hasConcept C104317684 @default.

• next