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- W2161529233 abstract "Abstract － Structural alterations of wogonin were conducted to observe the role of each functional group at the A-ring of wogonin on the inhibitory activities against COX-2 catalyzed PGE 2 production from LPS-induced RAW 264.7 cells. Serial deletion of the functional groups at the A-ring of wogonin exhibited low to comparable bioactivity. The present study validated that all the functional groups at the A-ring of wogonin are important factors to exhibit the optimum inhibitory activities.Keywords: Structural alterations, Wogonin, PGE 2 production, COX-2, Anti-inflammatory activity INTRODUCTION Flavonoids are naturally occurring polyphenolic com-pounds which possess a wide range of biological activities such as anti-inflammatory, anti-tumor and anti-oxidant (Read, 1995; Harborne and Williams, 2000). They are ubiquitously present in plant kingdom and also integral components abundant in our daily common diet. The vari-ous flavonoid of plant origin have been reported to pos-sess the inhibitory activity on cyclooxygenase and lip-oxygenase (Wakabayashi and Yasui, 2000; Chen" @default.
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- W2161529233 date "2009-10-31" @default.
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- W2161529233 title "Structural Alterations of Wogonin Significantly Reduce the Inhibitory Activity against COX-2 Catalyzed PGE<sub>2</sub>Production from LPS-Induced RAW 264.7 Cells" @default.
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- W2161529233 doi "https://doi.org/10.4062/biomolther.2009.17.4.418" @default.
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