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- W2161544223 abstract "Abstract Mesenchymal stem cells (MSCs) have acquired great interests for their potential use in the clinical therapy of many diseases because of their functions including multiple lineage differentiation, low immunogenicity and immunosuppression. Many studies suggest that MSCs are strongly immunosuppressive in vitro and in vivo . MSCs exert a profound inhibitory effect on the proliferation of T cells, B cells, dendritic cells and natural killer cells. In addition, several soluble factors have been reported to involved in the immunosuppressive effects by MSCs such as TGF-β, HGF, PGE2, IDO and iNOS. These results suggest that MSCs can be used in the therapy of immune disorder diseases, prevention of organ transplantation rejection and tissue injury. In recent study, we demonstrated that MSCs in tumor inflammatory microenvironment might be elicited of immunosuppressive function. Thus, the application of MSCs in cancer therapy might have negative effect by helping tumor cells escaping from the immune surveillance." @default.
- W2161544223 created "2016-06-24" @default.
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- W2161544223 date "2012-03-01" @default.
- W2161544223 modified "2023-10-15" @default.
- W2161544223 title "The role of immunosuppression of mesenchymal stem cells in tissue repair and tumor growth" @default.
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- W2161544223 doi "https://doi.org/10.1186/2045-3701-2-8" @default.
- W2161544223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3315743" @default.
- W2161544223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22390479" @default.
- W2161544223 hasPublicationYear "2012" @default.
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