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• W2161550107 abstract "<h3>Abstract</h3> Division and degradation of bacterial cell walls requires coordinated action of a myriad of enzymes. This particularly applies to the elaborate cell walls of acid-fast organisms such as <i>Mycobacterium tuberculosis</i>, which consist of a multi-layered cell wall that contains an unusual glycan called arabinogalactan. Enzymes that cleave the d-arabinan core of this structure have not previously been identified in any organism. We have interrogated the diverse carbohydrate degrading enzymes expressed by the human gut microbiota and uncovered four families of glycoside hydrolases with the capability to degrade the d-arabinan or d-galactan components of arabinogalactan. Using novel exo-d-galactofuranosidases from gut bacteria we generated enriched d-arabinan and used it to identify <i>D. gadei</i> as a D-arabinan degrader. This enabled the discovery of endo- and exo-acting enzymes that cleave D-arabinan. We have identified new members of the DUF2961 family (GH172), and a novel family of glycoside hydrolases (DUF4185) that display endo-d-arabinofuranase activity. The DUF4185 enzymes are conserved in mycobacteria and found in many microbes, suggesting that the ability to degrade mycobacterial glycans plays an important role in the biology of diverse organisms. All mycobacteria encode two conserved endo-d-arabinanases that display different preferences for the d-arabinan-containing cell wall components arabinogalactan and lipoarabinomannan, suggesting they are important for cell wall modification and/or degradation. The discovery of these enzymes will support future studies into the structure and function of the mycobacterial cell wall." @default.
• W2161550107 created "2016-06-24" @default.
• W2161550107 creator A5033865967 @default.
• W2161550107 creator A5053030261 @default.
• W2161550107 creator A5056635579 @default.
• W2161550107 date "2013-06-27" @default.
• W2161550107 modified "2023-10-09" @default.
• W2161550107 title "Implementation of the FIFA 11+ football warm up program: How to approach and convince the Football associations to invest in prevention" @default.
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• W2161550107 doi "https://doi.org/10.1136/bjsports-2012-092124" @default.
• W2161550107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3717809" @default.
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