FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161551837> ?p ?o ?g. }

• W2161551837 endingPage "52" @default.
• W2161551837 startingPage "1145" @default.
• W2161551837 abstract "P-glycoprotein (PGP), an active efflux pump of antitumor agents in multidrug-resistant tumor cells, exists in brain capillary endothelium and could be functionally involved in the blood-brain barrier. To study the regulatory mechanism of PGP expression in brain capillary endothelium, various mouse tissue matrices were tested for their abilities to enhance the expression of PGP in mouse brain capillary endothelial cells (MBEC), which express relatively small amounts of PGP. Of the four tissue matrices we examined, PGP expression in MBEC cultured on the brain matrix increased 2.0-fold. The PGP-inducing activity was similarly detected in bovine brain matrix, and the activity was enriched in the fraction of pl 9.0 by isoelectric focusing. The fraction, named PIC-fraction (PGP-inducing component), increased the PGP expression in MBEC 3.5-fold. By Northern blot analysis, a 3.3-fold enhancement of mdr gene expression was observed in MBEC cultured on the PIC-fraction. The PGP-inducing activity of the PIC-fraction was reduced by the treatment with trypsin but not with collagenase, suggesting that a proteinaceous factor distinct from type I collagen might be responsible for the PGP-inducing activity of PIC-fraction. Although the PIC-fraction increased the PGP expression in other mouse brain capillary endothelial cells, the PIC-fraction did not increase PGP expression in mouse aortic endothelial cells and KB carcinoma cell lines expressing various amounts of PGP. These observations suggest that PGP expression in brain capillary endothelium is specifically regulated by a tissue-specific factor in the brain matrix." @default.
• W2161551837 created "2016-06-24" @default.
• W2161551837 creator A5022882777 @default.
• W2161551837 creator A5033231895 @default.
• W2161551837 creator A5035210412 @default.
• W2161551837 creator A5082394662 @default.
• W2161551837 date "1994-10-01" @default.
• W2161551837 modified "2023-10-01" @default.
• W2161551837 title "Enhanced expression by the brain matrix of P-glycoprotein in brain capillary endothelial cells." @default.
• W2161551837 cites W1480389906 @default.
• W2161551837 cites W1487550059 @default.
• W2161551837 cites W1497498736 @default.
• W2161551837 cites W1503726497 @default.
• W2161551837 cites W1518457310 @default.
• W2161551837 cites W1526872663 @default.
• W2161551837 cites W1538763799 @default.
• W2161551837 cites W1544973014 @default.
• W2161551837 cites W1569642404 @default.
• W2161551837 cites W1583339960 @default.
• W2161551837 cites W1596439003 @default.
• W2161551837 cites W1599886286 @default.
• W2161551837 cites W1605451242 @default.
• W2161551837 cites W1621520183 @default.
• W2161551837 cites W1624721816 @default.
• W2161551837 cites W1910121302 @default.
• W2161551837 cites W1923579966 @default.
• W2161551837 cites W1964470226 @default.
• W2161551837 cites W1970985290 @default.
• W2161551837 cites W2002555237 @default.
• W2161551837 cites W2003951022 @default.
• W2161551837 cites W2004181066 @default.
• W2161551837 cites W2005877531 @default.
• W2161551837 cites W2010579436 @default.
• W2161551837 cites W2013280216 @default.
• W2161551837 cites W2018652769 @default.
• W2161551837 cites W2020931673 @default.
• W2161551837 cites W2022961230 @default.
• W2161551837 cites W2024026482 @default.
• W2161551837 cites W2033021666 @default.
• W2161551837 cites W2037621239 @default.
• W2161551837 cites W2039068269 @default.
• W2161551837 cites W2046046960 @default.
• W2161551837 cites W2049683781 @default.
• W2161551837 cites W2049772927 @default.
• W2161551837 cites W2053963421 @default.
• W2161551837 cites W2058215061 @default.
• W2161551837 cites W2058825253 @default.
• W2161551837 cites W2060333964 @default.
• W2161551837 cites W2065171962 @default.
• W2161551837 cites W2069334190 @default.
• W2161551837 cites W2075749214 @default.
• W2161551837 cites W2076149108 @default.
• W2161551837 cites W2078877172 @default.
• W2161551837 cites W2081868313 @default.
• W2161551837 cites W2088822897 @default.
• W2161551837 cites W2092685043 @default.
• W2161551837 cites W2112001901 @default.
• W2161551837 cites W2112506274 @default.
• W2161551837 cites W2133245023 @default.
• W2161551837 cites W2134745887 @default.
• W2161551837 cites W2138993111 @default.
• W2161551837 cites W2151598389 @default.
• W2161551837 cites W2152353759 @default.
• W2161551837 cites W2153712534 @default.
• W2161551837 cites W2166728942 @default.
• W2161551837 cites W2198182531 @default.
• W2161551837 cites W2406054717 @default.
• W2161551837 cites W245747599 @default.
• W2161551837 cites W30098335 @default.
• W2161551837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7848916" @default.
• W2161551837 hasPublicationYear "1994" @default.
• W2161551837 type Work @default.
• W2161551837 sameAs 2161551837 @default.
• W2161551837 citedByCount "11" @default.
• W2161551837 countsByYear W21615518372018 @default.
• W2161551837 crossrefType "journal-article" @default.
• W2161551837 hasAuthorship W2161551837A5022882777 @default.
• W2161551837 hasAuthorship W2161551837A5033231895 @default.
• W2161551837 hasAuthorship W2161551837A5035210412 @default.
• W2161551837 hasAuthorship W2161551837A5082394662 @default.
• W2161551837 hasConcept C123012128 @default.
• W2161551837 hasConcept C133936738 @default.
• W2161551837 hasConcept C134018914 @default.
• W2161551837 hasConcept C153911025 @default.
• W2161551837 hasConcept C202751555 @default.
• W2161551837 hasConcept C2776992346 @default.
• W2161551837 hasConcept C2778402981 @default.
• W2161551837 hasConcept C2778707650 @default.
• W2161551837 hasConcept C501593827 @default.
• W2161551837 hasConcept C529278444 @default.
• W2161551837 hasConcept C54355233 @default.
• W2161551837 hasConcept C55493867 @default.
• W2161551837 hasConcept C81885089 @default.
• W2161551837 hasConcept C86803240 @default.
• W2161551837 hasConcept C95444343 @default.
• W2161551837 hasConceptScore W2161551837C123012128 @default.
• W2161551837 hasConceptScore W2161551837C133936738 @default.
• W2161551837 hasConceptScore W2161551837C134018914 @default.

• next