Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161553154> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2161553154 abstract "Neuroblastoma (NB) is an embryonal tumor originating from the simpatico‐adrenal lineage of the neural crest and developing virtually at any site of the sympathetic nervous system. It approximately accounts for about 15% of all paediatric oncology deaths. NB is characterized by different clinical presentations and courses. Metastatic tumors at diagnosis remains a clinical challenge, despite advances in multimodal therapy. Retinoids are a class of compounds known to induce both terminal differentiation and apoptosis/necrosis of NB cells. Among them, fenretinide (HPR), thanks to its good safety profile in humans, has been considered one of the most promising synthetic retinoids tested as chemopreventive agent but it is only partially efficacious due to both a scanty oral delivery and a rapid methabolism. Here, we have developed a novel liposomal HPR by which the drug was encapsulated into sterically stabilized liposomes [SL‐(HPR)] according to the reverse‐phase evaporation method. This procedure led to a higher drug encapsulation and to better size and stability in organic fluids when compared to our previously HPR‐entrapped liposome preparation (Pagnan et al., Int.J.Cancer 1999;81:268). Moreover, liposomes were coupled with NGR peptides that target the tumor endothelial cell marker, the aminopeptidase N [NGR‐SL‐(HPR)] (Pastorino et al, Cancer Res 2006;66:10073). The in vivo sensitivity of NB to the HPR liposomal preparations was tested against an established orthotopic NB xenograft animal model. Tumor‐bearing mice treated with NGR‐SL‐(HPR) lived statistically longer than mice un‐treated or treated with free HPR [NGR‐SL‐(HPR) vs both control and HPR: P The use of this novel targeted delivery system for the apoptotic and anti‐angiogenic drug, fenretinide, could be considered as an adjuvant tool in the future treatment of NB patients. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):A130." @default.
- W2161553154 created "2016-06-24" @default.
- W2161553154 creator A5014918411 @default.
- W2161553154 creator A5027704478 @default.
- W2161553154 creator A5029980009 @default.
- W2161553154 creator A5035931487 @default.
- W2161553154 creator A5041501501 @default.
- W2161553154 creator A5042376678 @default.
- W2161553154 creator A5046260922 @default.
- W2161553154 creator A5053922930 @default.
- W2161553154 creator A5062757807 @default.
- W2161553154 creator A5070223734 @default.
- W2161553154 creator A5070686436 @default.
- W2161553154 date "2009-12-10" @default.
- W2161553154 modified "2023-09-27" @default.
- W2161553154 title "Abstract A130: Effects of a novel liposomal formulation of fenretinide on human neuroblastoma cell growth, apoptosis and angiogenesis" @default.
- W2161553154 doi "https://doi.org/10.1158/1535-7163.targ-09-a130" @default.
- W2161553154 hasPublicationYear "2009" @default.
- W2161553154 type Work @default.
- W2161553154 sameAs 2161553154 @default.
- W2161553154 citedByCount "0" @default.
- W2161553154 crossrefType "proceedings-article" @default.
- W2161553154 hasAuthorship W2161553154A5014918411 @default.
- W2161553154 hasAuthorship W2161553154A5027704478 @default.
- W2161553154 hasAuthorship W2161553154A5029980009 @default.
- W2161553154 hasAuthorship W2161553154A5035931487 @default.
- W2161553154 hasAuthorship W2161553154A5041501501 @default.
- W2161553154 hasAuthorship W2161553154A5042376678 @default.
- W2161553154 hasAuthorship W2161553154A5046260922 @default.
- W2161553154 hasAuthorship W2161553154A5053922930 @default.
- W2161553154 hasAuthorship W2161553154A5062757807 @default.
- W2161553154 hasAuthorship W2161553154A5070223734 @default.
- W2161553154 hasAuthorship W2161553154A5070686436 @default.
- W2161553154 hasConcept C150903083 @default.
- W2161553154 hasConcept C185154212 @default.
- W2161553154 hasConcept C185592680 @default.
- W2161553154 hasConcept C190283241 @default.
- W2161553154 hasConcept C207001950 @default.
- W2161553154 hasConcept C2775954498 @default.
- W2161553154 hasConcept C2776715637 @default.
- W2161553154 hasConcept C2780394083 @default.
- W2161553154 hasConcept C2780533455 @default.
- W2161553154 hasConcept C2781121885 @default.
- W2161553154 hasConcept C502942594 @default.
- W2161553154 hasConcept C54355233 @default.
- W2161553154 hasConcept C55493867 @default.
- W2161553154 hasConcept C71924100 @default.
- W2161553154 hasConcept C81885089 @default.
- W2161553154 hasConcept C86803240 @default.
- W2161553154 hasConcept C98274493 @default.
- W2161553154 hasConceptScore W2161553154C150903083 @default.
- W2161553154 hasConceptScore W2161553154C185154212 @default.
- W2161553154 hasConceptScore W2161553154C185592680 @default.
- W2161553154 hasConceptScore W2161553154C190283241 @default.
- W2161553154 hasConceptScore W2161553154C207001950 @default.
- W2161553154 hasConceptScore W2161553154C2775954498 @default.
- W2161553154 hasConceptScore W2161553154C2776715637 @default.
- W2161553154 hasConceptScore W2161553154C2780394083 @default.
- W2161553154 hasConceptScore W2161553154C2780533455 @default.
- W2161553154 hasConceptScore W2161553154C2781121885 @default.
- W2161553154 hasConceptScore W2161553154C502942594 @default.
- W2161553154 hasConceptScore W2161553154C54355233 @default.
- W2161553154 hasConceptScore W2161553154C55493867 @default.
- W2161553154 hasConceptScore W2161553154C71924100 @default.
- W2161553154 hasConceptScore W2161553154C81885089 @default.
- W2161553154 hasConceptScore W2161553154C86803240 @default.
- W2161553154 hasConceptScore W2161553154C98274493 @default.
- W2161553154 hasLocation W21615531541 @default.
- W2161553154 hasOpenAccess W2161553154 @default.
- W2161553154 hasPrimaryLocation W21615531541 @default.
- W2161553154 hasRelatedWork W1756308817 @default.
- W2161553154 hasRelatedWork W1970594267 @default.
- W2161553154 hasRelatedWork W1995986211 @default.
- W2161553154 hasRelatedWork W2007597753 @default.
- W2161553154 hasRelatedWork W2009013228 @default.
- W2161553154 hasRelatedWork W2014778950 @default.
- W2161553154 hasRelatedWork W2021233105 @default.
- W2161553154 hasRelatedWork W2081367905 @default.
- W2161553154 hasRelatedWork W2083716957 @default.
- W2161553154 hasRelatedWork W2101610367 @default.
- W2161553154 hasRelatedWork W2140172368 @default.
- W2161553154 hasRelatedWork W2151057281 @default.
- W2161553154 hasRelatedWork W2312358555 @default.
- W2161553154 hasRelatedWork W2520310718 @default.
- W2161553154 hasRelatedWork W2530659680 @default.
- W2161553154 hasRelatedWork W2621228952 @default.
- W2161553154 hasRelatedWork W2622931104 @default.
- W2161553154 hasRelatedWork W2753057159 @default.
- W2161553154 hasRelatedWork W2786714044 @default.
- W2161553154 hasRelatedWork W3080861933 @default.
- W2161553154 isParatext "false" @default.
- W2161553154 isRetracted "false" @default.
- W2161553154 magId "2161553154" @default.
- W2161553154 workType "article" @default.