Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161566096> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2161566096 endingPage "313" @default.
- W2161566096 startingPage "308" @default.
- W2161566096 abstract "Abstract Tetrahydro-β-carbolines (THBCs), 6-methoxyharmalan and norharman and the corresponding open chain tryptamines studied inhibited 5-hydroxytryptamine (5-HT) and dopamine (DA) uptake in human blood platelets. 1-methyl-THBCs were better inhibitors of DA than 5-HT uptake but THBCs generally were far more potent inhibitors of 5-HT uptake than of DA uptake. 6-methoxy-1,2,3,4-tetrahydro-β-carboline was as potent as 5-HT itself in 3H-5-HT uptake inhibition in platelets and the inhibition was competitive. All the β-carbolines studied were more potent inhibitors of 3H-DA uptake than DA itself. Contrary to results in rat brain synaptosomes, THBCs were more potent in platelets than the corresponding tryptamines with the freely rotating ethylamine side chain. Unsaturated β-carbolines were weaker inhibitors than THBCs. The clear difference in the rank order of potencies of these compounds in human platelets and rat brain synaptosomes demonstrates that these different model systems for amine uptake studies do not always give comparable results. The results also suggest that there are differences in the uptake systems for 5-HT and DA in human platelets." @default.
- W2161566096 created "2016-06-24" @default.
- W2161566096 creator A5011985392 @default.
- W2161566096 creator A5034460373 @default.
- W2161566096 creator A5042532892 @default.
- W2161566096 creator A5058191124 @default.
- W2161566096 date "2009-03-13" @default.
- W2161566096 modified "2023-09-26" @default.
- W2161566096 title "Tetrahydro-β-carbolines and Corresponding Tryptamines: In Vitro Inhibition of Serotonin and Dopamine Uptake by Human Blood Platelets" @default.
- W2161566096 cites W1964563096 @default.
- W2161566096 cites W1966750852 @default.
- W2161566096 cites W1968028332 @default.
- W2161566096 cites W1974706988 @default.
- W2161566096 cites W1982307685 @default.
- W2161566096 cites W1993979684 @default.
- W2161566096 cites W2002597738 @default.
- W2161566096 cites W2004922157 @default.
- W2161566096 cites W2029070249 @default.
- W2161566096 cites W2029546712 @default.
- W2161566096 cites W2030586524 @default.
- W2161566096 cites W2036756044 @default.
- W2161566096 cites W2065986749 @default.
- W2161566096 cites W2088287574 @default.
- W2161566096 cites W2101264301 @default.
- W2161566096 cites W2109350696 @default.
- W2161566096 cites W2113399915 @default.
- W2161566096 cites W2135112754 @default.
- W2161566096 doi "https://doi.org/10.1111/j.1600-0773.1980.tb02459.x" @default.
- W2161566096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7368950" @default.
- W2161566096 hasPublicationYear "2009" @default.
- W2161566096 type Work @default.
- W2161566096 sameAs 2161566096 @default.
- W2161566096 citedByCount "27" @default.
- W2161566096 countsByYear W21615660962012 @default.
- W2161566096 countsByYear W21615660962014 @default.
- W2161566096 countsByYear W21615660962015 @default.
- W2161566096 countsByYear W21615660962020 @default.
- W2161566096 crossrefType "journal-article" @default.
- W2161566096 hasAuthorship W2161566096A5011985392 @default.
- W2161566096 hasAuthorship W2161566096A5034460373 @default.
- W2161566096 hasAuthorship W2161566096A5042532892 @default.
- W2161566096 hasAuthorship W2161566096A5058191124 @default.
- W2161566096 hasConcept C126322002 @default.
- W2161566096 hasConcept C134018914 @default.
- W2161566096 hasConcept C170493617 @default.
- W2161566096 hasConcept C178790620 @default.
- W2161566096 hasConcept C185592680 @default.
- W2161566096 hasConcept C202751555 @default.
- W2161566096 hasConcept C2775864247 @default.
- W2161566096 hasConcept C2777135210 @default.
- W2161566096 hasConcept C2778678469 @default.
- W2161566096 hasConcept C2909645108 @default.
- W2161566096 hasConcept C2909786974 @default.
- W2161566096 hasConcept C513476851 @default.
- W2161566096 hasConcept C55493867 @default.
- W2161566096 hasConcept C71240020 @default.
- W2161566096 hasConcept C71924100 @default.
- W2161566096 hasConcept C86803240 @default.
- W2161566096 hasConcept C89560881 @default.
- W2161566096 hasConcept C98274493 @default.
- W2161566096 hasConceptScore W2161566096C126322002 @default.
- W2161566096 hasConceptScore W2161566096C134018914 @default.
- W2161566096 hasConceptScore W2161566096C170493617 @default.
- W2161566096 hasConceptScore W2161566096C178790620 @default.
- W2161566096 hasConceptScore W2161566096C185592680 @default.
- W2161566096 hasConceptScore W2161566096C202751555 @default.
- W2161566096 hasConceptScore W2161566096C2775864247 @default.
- W2161566096 hasConceptScore W2161566096C2777135210 @default.
- W2161566096 hasConceptScore W2161566096C2778678469 @default.
- W2161566096 hasConceptScore W2161566096C2909645108 @default.
- W2161566096 hasConceptScore W2161566096C2909786974 @default.
- W2161566096 hasConceptScore W2161566096C513476851 @default.
- W2161566096 hasConceptScore W2161566096C55493867 @default.
- W2161566096 hasConceptScore W2161566096C71240020 @default.
- W2161566096 hasConceptScore W2161566096C71924100 @default.
- W2161566096 hasConceptScore W2161566096C86803240 @default.
- W2161566096 hasConceptScore W2161566096C89560881 @default.
- W2161566096 hasConceptScore W2161566096C98274493 @default.
- W2161566096 hasIssue "4" @default.
- W2161566096 hasLocation W21615660961 @default.
- W2161566096 hasLocation W21615660962 @default.
- W2161566096 hasOpenAccess W2161566096 @default.
- W2161566096 hasPrimaryLocation W21615660961 @default.
- W2161566096 hasRelatedWork W1981301983 @default.
- W2161566096 hasRelatedWork W1990006882 @default.
- W2161566096 hasRelatedWork W2010250078 @default.
- W2161566096 hasRelatedWork W2026591087 @default.
- W2161566096 hasRelatedWork W2081272088 @default.
- W2161566096 hasRelatedWork W2439492537 @default.
- W2161566096 hasRelatedWork W2745975567 @default.
- W2161566096 hasRelatedWork W4300865734 @default.
- W2161566096 hasRelatedWork W4304774418 @default.
- W2161566096 hasRelatedWork W83147188 @default.
- W2161566096 hasVolume "46" @default.
- W2161566096 isParatext "false" @default.
- W2161566096 isRetracted "false" @default.
- W2161566096 magId "2161566096" @default.
- W2161566096 workType "article" @default.