FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161567473> ?p ?o ?g. }

• W2161567473 endingPage "513" @default.
• W2161567473 startingPage "506" @default.
• W2161567473 abstract "BackgroundThe molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that alterations in expression levels of specific fibrillar collagens occur during the aneurysmal process.MethodsSurgical samples from ascending aortas from patients with degenerative ATAAs were subdivided by aneurysm diameter: small, 5 to 6 cm; medium, 6 to 7 cm; and large, greater than 7 cm; and compared with nonaneurysmal aortas (mean diameter, 2.3 cm).ResultsHistology, immunofluorescence, and electron microscopy demonstrated greater disorganization of extracellular matrix constituents in ATAAs as compared with control with an increase in collagen α1(XI) within regions of cystic medial degenerative lesions. Real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) showed collagens type V and α1(XI) were significantly and linearly increased in ATAAs as compared with control (p < 0.001). There was no change in the messenger ribonucleic acid (mRNA) expression levels of collagens type I and III. Western blot analysis showed collagens type I and III were significantly decreased and collagens α1(XI) and V were significantly increased and were linearly correlated with the size of the aneurysm (p < 0.001 for both).ConclusionsThese results demonstrate that increased collagen α1(XI) and collagen V mRNA and protein levels are linearly correlated with the size of the aneurysm and provide a potential mechanism for the generation and progression of aneurysmal enlargement. The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that alterations in expression levels of specific fibrillar collagens occur during the aneurysmal process. Surgical samples from ascending aortas from patients with degenerative ATAAs were subdivided by aneurysm diameter: small, 5 to 6 cm; medium, 6 to 7 cm; and large, greater than 7 cm; and compared with nonaneurysmal aortas (mean diameter, 2.3 cm). Histology, immunofluorescence, and electron microscopy demonstrated greater disorganization of extracellular matrix constituents in ATAAs as compared with control with an increase in collagen α1(XI) within regions of cystic medial degenerative lesions. Real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) showed collagens type V and α1(XI) were significantly and linearly increased in ATAAs as compared with control (p < 0.001). There was no change in the messenger ribonucleic acid (mRNA) expression levels of collagens type I and III. Western blot analysis showed collagens type I and III were significantly decreased and collagens α1(XI) and V were significantly increased and were linearly correlated with the size of the aneurysm (p < 0.001 for both). These results demonstrate that increased collagen α1(XI) and collagen V mRNA and protein levels are linearly correlated with the size of the aneurysm and provide a potential mechanism for the generation and progression of aneurysmal enlargement." @default.
• W2161567473 created "2016-06-24" @default.
• W2161567473 creator A5008795581 @default.
• W2161567473 creator A5018771256 @default.
• W2161567473 creator A5025021235 @default.
• W2161567473 creator A5028259526 @default.
• W2161567473 creator A5029063699 @default.
• W2161567473 creator A5029815474 @default.
• W2161567473 creator A5038343851 @default.
• W2161567473 creator A5053928073 @default.
• W2161567473 creator A5057017311 @default.
• W2161567473 creator A5057234706 @default.
• W2161567473 creator A5085052926 @default.
• W2161567473 creator A5086550126 @default.
• W2161567473 creator A5088674752 @default.
• W2161567473 date "2009-08-01" @default.
• W2161567473 modified "2023-09-24" @default.
• W2161567473 title "Differential Expression of Collagen Type V and XI α-1 in Human Ascending Thoracic Aortic Aneurysms" @default.
• W2161567473 cites W1965078322 @default.
• W2161567473 cites W1977604129 @default.
• W2161567473 cites W1981140366 @default.
• W2161567473 cites W2002645144 @default.
• W2161567473 cites W2013538302 @default.
• W2161567473 cites W2023646321 @default.
• W2161567473 cites W2035404452 @default.
• W2161567473 cites W2039830387 @default.
• W2161567473 cites W2049069266 @default.
• W2161567473 cites W2049210107 @default.
• W2161567473 cites W2073091304 @default.
• W2161567473 cites W2084575098 @default.
• W2161567473 cites W2085999436 @default.
• W2161567473 cites W2086463748 @default.
• W2161567473 cites W2094576781 @default.
• W2161567473 cites W2095944775 @default.
• W2161567473 cites W2099555515 @default.
• W2161567473 cites W2100139763 @default.
• W2161567473 cites W2108244474 @default.
• W2161567473 cites W2137423684 @default.
• W2161567473 cites W2141871922 @default.
• W2161567473 cites W2154953393 @default.
• W2161567473 cites W2158975686 @default.
• W2161567473 doi "https://doi.org/10.1016/j.athoracsur.2009.04.030" @default.
• W2161567473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2834780" @default.
• W2161567473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19632402" @default.
• W2161567473 hasPublicationYear "2009" @default.
• W2161567473 type Work @default.
• W2161567473 sameAs 2161567473 @default.
• W2161567473 citedByCount "25" @default.
• W2161567473 countsByYear W21615674732012 @default.
• W2161567473 countsByYear W21615674732013 @default.
• W2161567473 countsByYear W21615674732015 @default.
• W2161567473 countsByYear W21615674732017 @default.
• W2161567473 countsByYear W21615674732018 @default.
• W2161567473 countsByYear W21615674732019 @default.
• W2161567473 countsByYear W21615674732020 @default.
• W2161567473 countsByYear W21615674732021 @default.
• W2161567473 crossrefType "journal-article" @default.
• W2161567473 hasAuthorship W2161567473A5008795581 @default.
• W2161567473 hasAuthorship W2161567473A5018771256 @default.
• W2161567473 hasAuthorship W2161567473A5025021235 @default.
• W2161567473 hasAuthorship W2161567473A5028259526 @default.
• W2161567473 hasAuthorship W2161567473A5029063699 @default.
• W2161567473 hasAuthorship W2161567473A5029815474 @default.
• W2161567473 hasAuthorship W2161567473A5038343851 @default.
• W2161567473 hasAuthorship W2161567473A5053928073 @default.
• W2161567473 hasAuthorship W2161567473A5057017311 @default.
• W2161567473 hasAuthorship W2161567473A5057234706 @default.
• W2161567473 hasAuthorship W2161567473A5085052926 @default.
• W2161567473 hasAuthorship W2161567473A5086550126 @default.
• W2161567473 hasAuthorship W2161567473A5088674752 @default.
• W2161567473 hasBestOaLocation W21615674732 @default.
• W2161567473 hasConcept C104317684 @default.
• W2161567473 hasConcept C105580179 @default.
• W2161567473 hasConcept C105702510 @default.
• W2161567473 hasConcept C126322002 @default.
• W2161567473 hasConcept C141071460 @default.
• W2161567473 hasConcept C142724271 @default.
• W2161567473 hasConcept C153911025 @default.
• W2161567473 hasConcept C189165786 @default.
• W2161567473 hasConcept C2776098176 @default.
• W2161567473 hasConcept C2776415932 @default.
• W2161567473 hasConcept C2777323849 @default.
• W2161567473 hasConcept C2778249958 @default.
• W2161567473 hasConcept C2779869378 @default.
• W2161567473 hasConcept C2779980429 @default.
• W2161567473 hasConcept C2780847584 @default.
• W2161567473 hasConcept C4692481 @default.
• W2161567473 hasConcept C55493867 @default.
• W2161567473 hasConcept C71924100 @default.
• W2161567473 hasConcept C86803240 @default.
• W2161567473 hasConcept C95444343 @default.
• W2161567473 hasConceptScore W2161567473C104317684 @default.
• W2161567473 hasConceptScore W2161567473C105580179 @default.
• W2161567473 hasConceptScore W2161567473C105702510 @default.
• W2161567473 hasConceptScore W2161567473C126322002 @default.
• W2161567473 hasConceptScore W2161567473C141071460 @default.
• W2161567473 hasConceptScore W2161567473C142724271 @default.
• W2161567473 hasConceptScore W2161567473C153911025 @default.

• next