Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161569157> ?p ?o ?g. }
- W2161569157 endingPage "42" @default.
- W2161569157 startingPage "32" @default.
- W2161569157 abstract "The perirhinal cortex (Brodmann's area 35) is a multimodal area that is important for normal memory function. Specifically, perirhinal cortex is involved in the detection of novel objects and manifests neurofibrillary tangles in Alzheimer's disease very early in disease progression. We scanned ex vivo brain hemispheres at standard resolution (1 mm × 1 mm × 1 mm) to construct pial/white matter surfaces in FreeSurfer and scanned again at high resolution (120 μm × 120 μm × 120 μm) to determine cortical architectural boundaries. After labeling perirhinal area 35 in the high resolution images, we mapped the high resolution labels to the surface models to localize area 35 in fourteen cases. We validated the area boundaries determined using histological Nissl staining. To test the accuracy of the probabilistic mapping, we measured the Hausdorff distance between the predicted and true labels and found that the median Hausdorff distance was 4.0 mm for the left hemispheres (n = 7) and 3.2 mm for the right hemispheres (n = 7) across subjects. To show the utility of perirhinal localization, we mapped our labels to a subset of the Alzheimer's Disease Neuroimaging Initiative dataset and found decreased cortical thickness measures in mild cognitive impairment and Alzheimer's disease compared to controls in the predicted perirhinal area 35. Our ex vivo probabilistic mapping of the perirhinal cortex provides histologically validated, automated and accurate labeling of architectonic regions in the medial temporal lobe, and facilitates the analysis of atrophic changes in a large dataset for earlier detection and diagnosis." @default.
- W2161569157 created "2016-06-24" @default.
- W2161569157 creator A5005004760 @default.
- W2161569157 creator A5022543706 @default.
- W2161569157 creator A5022799533 @default.
- W2161569157 creator A5022828667 @default.
- W2161569157 creator A5036454720 @default.
- W2161569157 creator A5046761950 @default.
- W2161569157 creator A5047520245 @default.
- W2161569157 creator A5066567855 @default.
- W2161569157 creator A5081155754 @default.
- W2161569157 creator A5089547970 @default.
- W2161569157 date "2013-01-01" @default.
- W2161569157 modified "2023-10-17" @default.
- W2161569157 title "Predicting the location of human perirhinal cortex, Brodmann's area 35, from MRI" @default.
- W2161569157 cites W1272003059 @default.
- W2161569157 cites W1505548944 @default.
- W2161569157 cites W1541999330 @default.
- W2161569157 cites W1579329346 @default.
- W2161569157 cites W1898594078 @default.
- W2161569157 cites W1965572030 @default.
- W2161569157 cites W1968723344 @default.
- W2161569157 cites W1970240370 @default.
- W2161569157 cites W1975769317 @default.
- W2161569157 cites W1975821649 @default.
- W2161569157 cites W1976076281 @default.
- W2161569157 cites W1978196727 @default.
- W2161569157 cites W1985612893 @default.
- W2161569157 cites W1991886821 @default.
- W2161569157 cites W1993940897 @default.
- W2161569157 cites W1999014668 @default.
- W2161569157 cites W2001486260 @default.
- W2161569157 cites W2004347786 @default.
- W2161569157 cites W2005760885 @default.
- W2161569157 cites W2013802001 @default.
- W2161569157 cites W2017976409 @default.
- W2161569157 cites W2029923284 @default.
- W2161569157 cites W2032574605 @default.
- W2161569157 cites W2035538155 @default.
- W2161569157 cites W2039706207 @default.
- W2161569157 cites W2041694959 @default.
- W2161569157 cites W2045231068 @default.
- W2161569157 cites W2045419273 @default.
- W2161569157 cites W2052742260 @default.
- W2161569157 cites W2058712341 @default.
- W2161569157 cites W2063136428 @default.
- W2161569157 cites W2066355557 @default.
- W2161569157 cites W2067822858 @default.
- W2161569157 cites W2068512330 @default.
- W2161569157 cites W2068996767 @default.
- W2161569157 cites W2070246276 @default.
- W2161569157 cites W2070455103 @default.
- W2161569157 cites W2072532706 @default.
- W2161569157 cites W2078524519 @default.
- W2161569157 cites W2080608455 @default.
- W2161569157 cites W2085764202 @default.
- W2161569157 cites W2088665704 @default.
- W2161569157 cites W2093898957 @default.
- W2161569157 cites W2096931656 @default.
- W2161569157 cites W2102185694 @default.
- W2161569157 cites W2110437310 @default.
- W2161569157 cites W2113319997 @default.
- W2161569157 cites W2114507444 @default.
- W2161569157 cites W2115281122 @default.
- W2161569157 cites W2117897811 @default.
- W2161569157 cites W2122328291 @default.
- W2161569157 cites W2122358852 @default.
- W2161569157 cites W2124114508 @default.
- W2161569157 cites W2133459825 @default.
- W2161569157 cites W2136139627 @default.
- W2161569157 cites W2137022539 @default.
- W2161569157 cites W2139209606 @default.
- W2161569157 cites W2144285465 @default.
- W2161569157 cites W2151721316 @default.
- W2161569157 cites W2154457867 @default.
- W2161569157 cites W2155963684 @default.
- W2161569157 cites W2156676059 @default.
- W2161569157 cites W2156719412 @default.
- W2161569157 cites W2157270343 @default.
- W2161569157 cites W2157325548 @default.
- W2161569157 cites W2157666661 @default.
- W2161569157 cites W2158233238 @default.
- W2161569157 cites W2160663597 @default.
- W2161569157 cites W2164158068 @default.
- W2161569157 cites W2171808809 @default.
- W2161569157 cites W2738397984 @default.
- W2161569157 cites W4232914543 @default.
- W2161569157 cites W4249221250 @default.
- W2161569157 cites W4249444920 @default.
- W2161569157 cites W4376849741 @default.
- W2161569157 cites W57510132 @default.
- W2161569157 doi "https://doi.org/10.1016/j.neuroimage.2012.08.071" @default.
- W2161569157 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3508349" @default.
- W2161569157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22960087" @default.
- W2161569157 hasPublicationYear "2013" @default.
- W2161569157 type Work @default.
- W2161569157 sameAs 2161569157 @default.
- W2161569157 citedByCount "76" @default.