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• W2161570787 abstract "A series of novel 1H-pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes was prepared and screened at selected dopamine receptor subtypes. Compound 4 (NGB 4420) displayed high affinity and selectivity (>100-fold) for the D(4) over D(2) and other CNS receptors. This compound was identified as a D(4) antagonist via its attenuation of dopamine agonist-induced GTPgamma(35)S binding at D(4) receptor." @default.
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• W2161570787 date "2003-09-01" @default.
• W2161570787 modified "2023-09-24" @default.
• W2161570787 title "1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: A unique structural class of dopamine D4 selective ligands" @default.
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• W2161570787 doi "https://doi.org/10.1016/s0960-894x(03)00587-0" @default.
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