Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161583198> ?p ?o ?g. }
- W2161583198 endingPage "31" @default.
- W2161583198 startingPage "1" @default.
- W2161583198 abstract "Noncytotoxic anticancer α-galactosphingolipid agelasphin-9b (1) was isolated in 1993 from an Okinawan marine sponge. Since then, a large number of natural and synthetic glycolipids were bioassayed as immunostimulants, which activate natural killer T cells to generate cytokines such as interferon γ (IFN-γ) and interleukin 4 (IL-4). Some of them (2–6) are known to be drug candidates for autoimmune disease or cancer.Download : Download full-size image Our chapter will review the methods used for the synthesis of these compounds, and also the structure–activity relationships among them. Recent biological and X-ray crystallographic studies show that each of the glycolipids is a ligand to make a complex with CD1d protein, and the complex can be recognized by T-cell receptor to induce the generation of cytokines such as IFN-γ and IL-4. Accordingly, it is important to identify the naturally occurring ligand(s) in animal bodies. In 2011, 7 (β-GluCer) was proposed as the natural and endogenous ligand. Synthesis and bioassay of 7 and its relatives will also be reviewed.Download : Download full-size image Finally, future clinical application of these noncytotoxic immunostimulants will be discussed. (for a previous review please, see K. Mori, T. Tashiro, Heterocycles, 2011, 83, 951–1003.)" @default.
- W2161583198 created "2016-06-24" @default.
- W2161583198 creator A5002772629 @default.
- W2161583198 creator A5052921908 @default.
- W2161583198 date "2014-01-01" @default.
- W2161583198 modified "2023-09-26" @default.
- W2161583198 title "Glycosphingolipid Ligands for Invariant Natural Killer T cells as Immunostimulants" @default.
- W2161583198 cites W1538172952 @default.
- W2161583198 cites W1542562398 @default.
- W2161583198 cites W1570336130 @default.
- W2161583198 cites W1797331631 @default.
- W2161583198 cites W1879507323 @default.
- W2161583198 cites W1900894033 @default.
- W2161583198 cites W1965002974 @default.
- W2161583198 cites W1965621413 @default.
- W2161583198 cites W1966204602 @default.
- W2161583198 cites W1966758216 @default.
- W2161583198 cites W1969310344 @default.
- W2161583198 cites W1969743297 @default.
- W2161583198 cites W1973784801 @default.
- W2161583198 cites W1974936220 @default.
- W2161583198 cites W1976710853 @default.
- W2161583198 cites W1981288085 @default.
- W2161583198 cites W1991083242 @default.
- W2161583198 cites W1992523113 @default.
- W2161583198 cites W2000653530 @default.
- W2161583198 cites W2002337438 @default.
- W2161583198 cites W2004122281 @default.
- W2161583198 cites W2005758450 @default.
- W2161583198 cites W2010647116 @default.
- W2161583198 cites W2012988191 @default.
- W2161583198 cites W2013660817 @default.
- W2161583198 cites W2013752600 @default.
- W2161583198 cites W2014433507 @default.
- W2161583198 cites W2014540590 @default.
- W2161583198 cites W2016003221 @default.
- W2161583198 cites W2016750734 @default.
- W2161583198 cites W2019934240 @default.
- W2161583198 cites W2020397832 @default.
- W2161583198 cites W2028452125 @default.
- W2161583198 cites W2033443495 @default.
- W2161583198 cites W2036850741 @default.
- W2161583198 cites W2037085755 @default.
- W2161583198 cites W2037980239 @default.
- W2161583198 cites W2038713569 @default.
- W2161583198 cites W2039558279 @default.
- W2161583198 cites W2040543116 @default.
- W2161583198 cites W2042839372 @default.
- W2161583198 cites W2045685954 @default.
- W2161583198 cites W2049521781 @default.
- W2161583198 cites W2049806716 @default.
- W2161583198 cites W2051568453 @default.
- W2161583198 cites W2053158464 @default.
- W2161583198 cites W2054017521 @default.
- W2161583198 cites W2054683727 @default.
- W2161583198 cites W2057117951 @default.
- W2161583198 cites W2059313909 @default.
- W2161583198 cites W2060111687 @default.
- W2161583198 cites W2062403869 @default.
- W2161583198 cites W2062533437 @default.
- W2161583198 cites W2062927527 @default.
- W2161583198 cites W2063590695 @default.
- W2161583198 cites W2064858323 @default.
- W2161583198 cites W2067238631 @default.
- W2161583198 cites W2067968902 @default.
- W2161583198 cites W2070008724 @default.
- W2161583198 cites W2073232640 @default.
- W2161583198 cites W2077372809 @default.
- W2161583198 cites W2079165366 @default.
- W2161583198 cites W2082558912 @default.
- W2161583198 cites W2083052520 @default.
- W2161583198 cites W2085116778 @default.
- W2161583198 cites W2087383063 @default.
- W2161583198 cites W2091355888 @default.
- W2161583198 cites W2093497258 @default.
- W2161583198 cites W2093818576 @default.
- W2161583198 cites W2100606990 @default.
- W2161583198 cites W2102355478 @default.
- W2161583198 cites W2103794578 @default.
- W2161583198 cites W2112413404 @default.
- W2161583198 cites W2116232985 @default.
- W2161583198 cites W2122130567 @default.
- W2161583198 cites W2126161157 @default.
- W2161583198 cites W2134690218 @default.
- W2161583198 cites W2141795482 @default.
- W2161583198 cites W2143220826 @default.
- W2161583198 cites W2149188050 @default.
- W2161583198 cites W2150757486 @default.
- W2161583198 cites W2150888484 @default.
- W2161583198 cites W2151164793 @default.
- W2161583198 cites W2152655356 @default.
- W2161583198 cites W2155604981 @default.
- W2161583198 cites W2155672162 @default.
- W2161583198 cites W2156472038 @default.
- W2161583198 cites W2159891985 @default.
- W2161583198 cites W2161307276 @default.
- W2161583198 cites W2162601620 @default.
- W2161583198 cites W2168055580 @default.