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- W2161592012 abstract "In The Lancet, Sophie Jamal and colleagues 1 Jamal SA Vandermeer B Raggi P et al. Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis. Lancet. 2013; (published online July 19.)http://dx.doi.org/10.1016/S0140-6736(13)60897-1 PubMed Google Scholar report an updated systematic review and meta-analysis of the effect on mortality of treatment of chronic kidney disease hyperphosphataemia with calcium-based versus non-calcium-based phosphate binders. Kidneys excrete excess dietary phosphate, therefore loss of renal function leads to a positive phosphate balance that ultimately results in hyperphosphataemia. Excess phosphate might deposit in soft tissues, most notably the cardiovascular system, as calcium phosphate salts. Observational studies have linked high serum phosphate concentrations with adverse outcomes in patients with chronic kidney disease and, more recently, the general population. 2 Gonzalez-Parra E Tuñón J Egido J Ortiz A Phosphate: a stealthier killer than previously thought?. Cardiovasc Pathol. 2012; 21: 372-381 Summary Full Text Full Text PDF PubMed Scopus (55) Google Scholar The phosphate removal capacity of dialysis is limited. Thus, chronic kidney disease clinical practice guidelines suggest dietary restriction of phosphate and use of phosphate binders to treat hyperphosphataemia. 3 Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work GroupKDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl. 2009; 113: S1-13 PubMed Google Scholar Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysisNon-calcium-based phosphate binders are associated with a decreased risk of all-cause mortality compared with calcium-based phosphate binders in patients with chronic kidney disease. Further studies are needed to identify causes of mortality and to assess whether mortality differs by type of non-calcium-based phosphate binder. Full-Text PDF" @default.
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- W2161592012 date "2013-10-01" @default.
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- W2161592012 title "The demise of calcium-based phosphate binders" @default.
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- W2161592012 doi "https://doi.org/10.1016/s0140-6736(13)61165-4" @default.
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