Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161621949> ?p ?o ?g. }
- W2161621949 abstract "In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe malaria resulting in high rates of pediatric morbidity and mortality in these regions. Previous studies associated interleukin (IL)-13 with pathogenesis of different infectious diseases, including P. falciparum malaria. However, the functional roles of polymorphic variants within the IL-13 promoter in conditioning susceptibility to SMA remain largely unexplored. As such, the association between the IL-13 variants -7402 T/G (rs7719175) and -4729G/A (rs3091307) and susceptibility to SMA was determined in children (n = 387) presenting with clinical symptoms of falciparum malaria and resident in a holoendemic transmission region in western Kenya. Our results indicated no difference in the proportions of individual genotypes among children presenting with non-SMA (n = 222) versus SMA (n = 165). Similarly, there was no associations between the individual genotypes (-7402 T/G and -4729G/A) and SMA. Additional analyses, however, revealed that proportions of individuals with -7402 T/-4729A (TA) haplotype was significantly higher in children presenting with SMA than non-SMA group (P = 0.043). A further multivariate logistic regression analyses, controlling for confounding factors, demonstrated that carriage of the TA haplotype was associated with increased susceptibility to SMA (OR; 1.564, 95% CI; 1.023-2.389, P = 0.039). In addition, circulating levels of IL-13 were comparable between the clinical groups as well as across genotypes and haplotypes. Collectively, findings presented here suggest that haplotypes within the IL-13 promoter at -7402 T/G and -4729G/A may modulate SMA pathogenesis, but do not affect circulating IL-13 levels." @default.
- W2161621949 created "2016-06-24" @default.
- W2161621949 creator A5000015672 @default.
- W2161621949 creator A5001399333 @default.
- W2161621949 creator A5022737094 @default.
- W2161621949 creator A5025541170 @default.
- W2161621949 creator A5042063773 @default.
- W2161621949 creator A5055501844 @default.
- W2161621949 creator A5077769878 @default.
- W2161621949 creator A5083803857 @default.
- W2161621949 creator A5088287870 @default.
- W2161621949 date "2013-03-25" @default.
- W2161621949 modified "2023-10-14" @default.
- W2161621949 title "Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels" @default.
- W2161621949 cites W1572255065 @default.
- W2161621949 cites W1812003545 @default.
- W2161621949 cites W1845019034 @default.
- W2161621949 cites W1872509458 @default.
- W2161621949 cites W1898143981 @default.
- W2161621949 cites W1939593001 @default.
- W2161621949 cites W1946638485 @default.
- W2161621949 cites W1964696594 @default.
- W2161621949 cites W1978673956 @default.
- W2161621949 cites W1987147264 @default.
- W2161621949 cites W1987909356 @default.
- W2161621949 cites W2000742079 @default.
- W2161621949 cites W2008555758 @default.
- W2161621949 cites W2018213286 @default.
- W2161621949 cites W2021678877 @default.
- W2161621949 cites W2032302447 @default.
- W2161621949 cites W2045135702 @default.
- W2161621949 cites W2054750142 @default.
- W2161621949 cites W2056846894 @default.
- W2161621949 cites W2058120223 @default.
- W2161621949 cites W2058401000 @default.
- W2161621949 cites W2067564501 @default.
- W2161621949 cites W2078968522 @default.
- W2161621949 cites W2085193829 @default.
- W2161621949 cites W2092844155 @default.
- W2161621949 cites W2097811192 @default.
- W2161621949 cites W2099554849 @default.
- W2161621949 cites W2110553928 @default.
- W2161621949 cites W2114804812 @default.
- W2161621949 cites W2117793275 @default.
- W2161621949 cites W2120471388 @default.
- W2161621949 cites W2124100296 @default.
- W2161621949 cites W2128627731 @default.
- W2161621949 cites W2130478463 @default.
- W2161621949 cites W2132665714 @default.
- W2161621949 cites W2140304835 @default.
- W2161621949 cites W2141710795 @default.
- W2161621949 cites W2146038653 @default.
- W2161621949 cites W2154215662 @default.
- W2161621949 cites W2154808121 @default.
- W2161621949 cites W2155531044 @default.
- W2161621949 cites W2155709177 @default.
- W2161621949 cites W2157458289 @default.
- W2161621949 cites W2159527878 @default.
- W2161621949 cites W2168938667 @default.
- W2161621949 cites W2395366663 @default.
- W2161621949 cites W4318471893 @default.
- W2161621949 doi "https://doi.org/10.1186/1471-2172-14-15" @default.
- W2161621949 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3618200" @default.
- W2161621949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23521898" @default.
- W2161621949 hasPublicationYear "2013" @default.
- W2161621949 type Work @default.
- W2161621949 sameAs 2161621949 @default.
- W2161621949 citedByCount "11" @default.
- W2161621949 countsByYear W21616219492014 @default.
- W2161621949 countsByYear W21616219492016 @default.
- W2161621949 countsByYear W21616219492018 @default.
- W2161621949 countsByYear W21616219492019 @default.
- W2161621949 countsByYear W21616219492022 @default.
- W2161621949 countsByYear W21616219492023 @default.
- W2161621949 crossrefType "journal-article" @default.
- W2161621949 hasAuthorship W2161621949A5000015672 @default.
- W2161621949 hasAuthorship W2161621949A5001399333 @default.
- W2161621949 hasAuthorship W2161621949A5022737094 @default.
- W2161621949 hasAuthorship W2161621949A5025541170 @default.
- W2161621949 hasAuthorship W2161621949A5042063773 @default.
- W2161621949 hasAuthorship W2161621949A5055501844 @default.
- W2161621949 hasAuthorship W2161621949A5077769878 @default.
- W2161621949 hasAuthorship W2161621949A5083803857 @default.
- W2161621949 hasAuthorship W2161621949A5088287870 @default.
- W2161621949 hasBestOaLocation W21616219491 @default.
- W2161621949 hasConcept C104317684 @default.
- W2161621949 hasConcept C114614502 @default.
- W2161621949 hasConcept C126322002 @default.
- W2161621949 hasConcept C135763542 @default.
- W2161621949 hasConcept C161921814 @default.
- W2161621949 hasConcept C197754878 @default.
- W2161621949 hasConcept C203014093 @default.
- W2161621949 hasConcept C2775867548 @default.
- W2161621949 hasConcept C2778048844 @default.
- W2161621949 hasConcept C2778248108 @default.
- W2161621949 hasConcept C2778371730 @default.
- W2161621949 hasConcept C33923547 @default.
- W2161621949 hasConcept C54355233 @default.
- W2161621949 hasConcept C71924100 @default.
- W2161621949 hasConcept C86803240 @default.