Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161625034> ?p ?o ?g. }
- W2161625034 endingPage "682" @default.
- W2161625034 startingPage "678" @default.
- W2161625034 abstract "Abstract While continuous chemical processes have attracted both academic and industrial interest, virtually all active pharmaceutical ingredients (APIs) are still produced by using multiple distinct batch processes. To date, methods for the divergent multistep continuous production of customizable small molecules are not available. A chemical assembly system was developed, in which flow‐reaction modules are linked together in an interchangeable fashion to give access to a wide breadth of chemical space. Control at three different levels—choice of starting material, reagent, or order of reaction modules—enables the synthesis of five APIs that represent three different structural classes (γ‐amino acids, γ‐lactams, β‐amino acids), including the blockbuster drugs Lyrica and Gabapentin, in good overall yields (49–75 %)." @default.
- W2161625034 created "2016-06-24" @default.
- W2161625034 creator A5005050488 @default.
- W2161625034 creator A5008512379 @default.
- W2161625034 creator A5046362326 @default.
- W2161625034 date "2014-11-20" @default.
- W2161625034 modified "2023-10-09" @default.
- W2161625034 title "Chemical Assembly Systems: Layered Control for Divergent, Continuous, Multistep Syntheses of Active Pharmaceutical Ingredients" @default.
- W2161625034 cites W1657914306 @default.
- W2161625034 cites W1965262876 @default.
- W2161625034 cites W1970785656 @default.
- W2161625034 cites W2004690997 @default.
- W2161625034 cites W2006275489 @default.
- W2161625034 cites W2017696617 @default.
- W2161625034 cites W2018605464 @default.
- W2161625034 cites W2019473876 @default.
- W2161625034 cites W2025168993 @default.
- W2161625034 cites W2035045727 @default.
- W2161625034 cites W2046505262 @default.
- W2161625034 cites W2057780605 @default.
- W2161625034 cites W2067759714 @default.
- W2161625034 cites W2068770175 @default.
- W2161625034 cites W2069958486 @default.
- W2161625034 cites W2071108652 @default.
- W2161625034 cites W2077954787 @default.
- W2161625034 cites W2078701683 @default.
- W2161625034 cites W2083415062 @default.
- W2161625034 cites W2088725132 @default.
- W2161625034 cites W2091977217 @default.
- W2161625034 cites W2111769894 @default.
- W2161625034 cites W2111820881 @default.
- W2161625034 cites W2112211764 @default.
- W2161625034 cites W2112739912 @default.
- W2161625034 cites W2122215898 @default.
- W2161625034 cites W2126363023 @default.
- W2161625034 cites W2128412489 @default.
- W2161625034 cites W2132245258 @default.
- W2161625034 cites W2133365461 @default.
- W2161625034 cites W2136155687 @default.
- W2161625034 cites W2139083301 @default.
- W2161625034 cites W2145550978 @default.
- W2161625034 cites W2150332288 @default.
- W2161625034 cites W2154790350 @default.
- W2161625034 cites W2158783483 @default.
- W2161625034 cites W2161653506 @default.
- W2161625034 cites W2168438282 @default.
- W2161625034 cites W2168588210 @default.
- W2161625034 cites W2170714350 @default.
- W2161625034 cites W2315861401 @default.
- W2161625034 cites W2321128093 @default.
- W2161625034 cites W2327586647 @default.
- W2161625034 cites W2333408635 @default.
- W2161625034 cites W4233399748 @default.
- W2161625034 cites W4240478805 @default.
- W2161625034 cites W4245528831 @default.
- W2161625034 cites W4252483718 @default.
- W2161625034 cites W4255873108 @default.
- W2161625034 cites W4256503849 @default.
- W2161625034 doi "https://doi.org/10.1002/anie.201409765" @default.
- W2161625034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25414136" @default.
- W2161625034 hasPublicationYear "2014" @default.
- W2161625034 type Work @default.
- W2161625034 sameAs 2161625034 @default.
- W2161625034 citedByCount "64" @default.
- W2161625034 countsByYear W21616250342015 @default.
- W2161625034 countsByYear W21616250342016 @default.
- W2161625034 countsByYear W21616250342017 @default.
- W2161625034 countsByYear W21616250342018 @default.
- W2161625034 countsByYear W21616250342019 @default.
- W2161625034 countsByYear W21616250342020 @default.
- W2161625034 countsByYear W21616250342021 @default.
- W2161625034 countsByYear W21616250342022 @default.
- W2161625034 countsByYear W21616250342023 @default.
- W2161625034 crossrefType "journal-article" @default.
- W2161625034 hasAuthorship W2161625034A5005050488 @default.
- W2161625034 hasAuthorship W2161625034A5008512379 @default.
- W2161625034 hasAuthorship W2161625034A5046362326 @default.
- W2161625034 hasConcept C114373084 @default.
- W2161625034 hasConcept C127413603 @default.
- W2161625034 hasConcept C171250308 @default.
- W2161625034 hasConcept C178790620 @default.
- W2161625034 hasConcept C183696295 @default.
- W2161625034 hasConcept C185592680 @default.
- W2161625034 hasConcept C192562407 @default.
- W2161625034 hasConcept C202751555 @default.
- W2161625034 hasConcept C21951064 @default.
- W2161625034 hasConcept C2985264121 @default.
- W2161625034 hasConcept C32909587 @default.
- W2161625034 hasConcept C40875361 @default.
- W2161625034 hasConcept C41008148 @default.
- W2161625034 hasConcept C45904493 @default.
- W2161625034 hasConcept C55493867 @default.
- W2161625034 hasConcept C60644358 @default.
- W2161625034 hasConcept C74187038 @default.
- W2161625034 hasConcept C86803240 @default.
- W2161625034 hasConcept C99726746 @default.
- W2161625034 hasConceptScore W2161625034C114373084 @default.
- W2161625034 hasConceptScore W2161625034C127413603 @default.