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- W2161630265 abstract "The effect of vitamin E on the modulation of keratinocytes was studied in rats. A 1% lauroylsarcosine (LS) ointment caused skin erythema with keratinocyte-damage. A 30% vitamin E ointment markedly alleviated this erythema and protected keratinocytes from cell damage. Vitamin E (100 μg/ml) was also effective on LS (7.5 μg/ml)-induced proliferative reduction of cultured keratinocytes. On the other hand, ointment containing superoxide dismutase (SOD) (99,000 U/g) decreased the LS-induced erythema, suggesting that superoxide anion (02−) produced from keratinocytes play an important role in the skin irritation. Indeed, LS induced 02-production from cultured keratinocytes. The 02-was significantly reduced by vitamin E and SOD, although vitamin E had no effects on O2− production in a xanthine-xanthine oxidase system, unlike the effect observed with SOD. These results indicate that vitamin E is an inhibitor of keratinocyte-modulation." @default.
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- W2161630265 date "1995-01-01" @default.
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- W2161630265 title "Effect of Vitamin E on Keratinocyte-Modulation Induced by Lauroylsarcosine" @default.
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- W2161630265 doi "https://doi.org/10.1254/jjp.67.291" @default.
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