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- W2161632561 endingPage "410" @default.
- W2161632561 startingPage "381" @default.
- W2161632561 abstract "▪ Abstract The protein variously named ABCG2/BCRP/MXR/ABCP is a recently described ATP-binding cassette (ABC) transporter originally identified by its ability to confer drug resistance that is independent of Mrp1 (multidrug-resistance protein 1) and Pgp (P-glycoprotein). Unlike Mrp1 and Pgp, ABCG2 is a half-transporter that must homodimerize to acquire transport activity. ABCG2 is found in a variety of stem cells and may protect them from exogenous and endogenous toxins. ABCG2 expression is upregulated under low-oxygen conditions, consistent with its high expression in tissues exposed to low-oxygen environments. ABCG2 interacts with heme and other porphyrins and protects cells and/or tissues from protoporphyrin accumulation under hypoxic conditions. Individuals who carry ABCG2 alleles that have impaired function may be more susceptible to porphyrin-induced toxicity. Abcg2 knock-out models have allowed in vivo studies of Abcg2 function in host and cellular defense. In combination with immunohistochemical analyses, these studies have revealed how ABCG2 influences the absorption, distribution, and excretion of drugs and cytotoxins." @default.
- W2161632561 created "2016-06-24" @default.
- W2161632561 creator A5056114856 @default.
- W2161632561 creator A5084371269 @default.
- W2161632561 date "2006-02-01" @default.
- W2161632561 modified "2023-09-27" @default.
- W2161632561 title "ROLE OF ABCG2/BCRP IN BIOLOGY AND MEDICINE" @default.
- W2161632561 cites W134011100 @default.
- W2161632561 cites W1483167997 @default.
- W2161632561 cites W1586955534 @default.
- W2161632561 cites W1647833960 @default.
- W2161632561 cites W1804694142 @default.
- W2161632561 cites W1925428032 @default.
- W2161632561 cites W1964724251 @default.
- W2161632561 cites W1967003022 @default.
- W2161632561 cites W1968108412 @default.
- W2161632561 cites W1968124824 @default.
- W2161632561 cites W1968172974 @default.
- W2161632561 cites W1968819069 @default.
- W2161632561 cites W1971274721 @default.
- W2161632561 cites W1972764534 @default.
- W2161632561 cites W1974447310 @default.
- W2161632561 cites W1974782765 @default.
- W2161632561 cites W1975202853 @default.
- W2161632561 cites W1977668920 @default.
- W2161632561 cites W1980132014 @default.
- W2161632561 cites W1980660848 @default.
- W2161632561 cites W1982352437 @default.
- W2161632561 cites W1984246155 @default.
- W2161632561 cites W1984737207 @default.
- W2161632561 cites W1986755882 @default.
- W2161632561 cites W1986796882 @default.
- W2161632561 cites W1988172699 @default.
- W2161632561 cites W1991652499 @default.
- W2161632561 cites W1993494709 @default.
- W2161632561 cites W1994711170 @default.
- W2161632561 cites W1996443605 @default.
- W2161632561 cites W1997048738 @default.
- W2161632561 cites W1998004891 @default.
- W2161632561 cites W1999004536 @default.
- W2161632561 cites W2001838995 @default.
- W2161632561 cites W2005531240 @default.
- W2161632561 cites W2007043808 @default.
- W2161632561 cites W2007049169 @default.
- W2161632561 cites W2007602523 @default.
- W2161632561 cites W2008790922 @default.
- W2161632561 cites W2011810742 @default.
- W2161632561 cites W2011988471 @default.
- W2161632561 cites W2011994267 @default.
- W2161632561 cites W2012841076 @default.
- W2161632561 cites W2013279579 @default.
- W2161632561 cites W2013540958 @default.
- W2161632561 cites W2017945990 @default.
- W2161632561 cites W2018301172 @default.
- W2161632561 cites W201908734 @default.
- W2161632561 cites W2020441233 @default.
- W2161632561 cites W2021428758 @default.
- W2161632561 cites W2021759214 @default.
- W2161632561 cites W2023345325 @default.
- W2161632561 cites W2023703396 @default.
- W2161632561 cites W2024679015 @default.
- W2161632561 cites W2028533496 @default.
- W2161632561 cites W2029142335 @default.
- W2161632561 cites W2031449582 @default.
- W2161632561 cites W2031785769 @default.
- W2161632561 cites W2033020367 @default.
- W2161632561 cites W2036172570 @default.
- W2161632561 cites W2036459315 @default.
- W2161632561 cites W2040383435 @default.
- W2161632561 cites W2043320183 @default.
- W2161632561 cites W2043846353 @default.
- W2161632561 cites W2048161767 @default.
- W2161632561 cites W2048729835 @default.
- W2161632561 cites W2049520769 @default.
- W2161632561 cites W2050189076 @default.
- W2161632561 cites W2051946794 @default.
- W2161632561 cites W2052209393 @default.
- W2161632561 cites W2053006297 @default.
- W2161632561 cites W2053659070 @default.
- W2161632561 cites W2055745286 @default.
- W2161632561 cites W2056598800 @default.
- W2161632561 cites W2057928306 @default.
- W2161632561 cites W2059153388 @default.
- W2161632561 cites W2059365007 @default.
- W2161632561 cites W2061198867 @default.
- W2161632561 cites W2062069198 @default.
- W2161632561 cites W2064266177 @default.
- W2161632561 cites W2069625044 @default.
- W2161632561 cites W2070691527 @default.
- W2161632561 cites W2071993498 @default.
- W2161632561 cites W2072046272 @default.
- W2161632561 cites W2074684937 @default.
- W2161632561 cites W2075293629 @default.
- W2161632561 cites W2076174476 @default.
- W2161632561 cites W2076845042 @default.
- W2161632561 cites W2077083084 @default.
- W2161632561 cites W2077673548 @default.
- W2161632561 cites W2078016671 @default.