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- W2161662401 abstract "Due to well-known markedly increased susceptibility contrast at ultra-high-field MR, this work is using 7T MR susceptibilty-weighted imaging (SWI) to better identify the histopathologic correlate of amyloid plaques containing iron and otherwise invisible subhippocampal structures of human post-mortem brain in patients with Alzheimer's disease. Post-mortem brain specimens of the frontal lobe and hippocampus were obtained from 8 patients (mean age 71.2±6.2 years) with clinically diagnosed AD and 6 age-matched healthy controls (72.4 ±6.6 years) without AD. Coronal 1∼3 cm thick brain slices were preserved and fixed in 2% agar or formalin for this study. Imaging was performed on a 7.0T MR. A 24-element phased array head coil was used. High resolution 3D SWI was obtained with isotropic voxel size 150∼320μm. For imaging optimization to better visualize amyloid plaques, we varied TR, TE, bandwidth and flip angle from 30-100ms, 12-36ms, 60-140Hz/pixel and 10-40°; respectively. Compared to controls, 7T SWI revealed a largely increased number of hypointense foci in AD brain samples along the cortical mantle of the frontal and entorhinal cortex due to enhanced susceptibility effects and superb signal. Figure 1 shows amyloid plaques identified with histologic slice (A) and in post-processed SWI image of the frontal cortex of an AD patient (B) as compared to a healthy control (C). The average phase value in the cortex region of AD data (2296 ± 72) is significantly higher than that of control data (2032 ± 64), which indicates higher iron amount in AD samples. In addition, 7T SWI also provides high resolution images for subregional hippocampal structures including CA1, CA2, CA3, subiculum, and dentate gyrus with significant atrophy of these structures in AD patients." @default.
- W2161662401 created "2016-06-24" @default.
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- W2161662401 date "2012-07-01" @default.
- W2161662401 modified "2023-09-27" @default.
- W2161662401 title "P4-180: 7 Tesla MR susceptibility-contrast microscopy imaging of amyloid pathology and the hippocampus in Alzheimer's disease" @default.
- W2161662401 doi "https://doi.org/10.1016/j.jalz.2012.05.1884" @default.
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