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- W2161662861 abstract "Mechanoelectric transduction can initiate cardiac arrhythmias. To examine the origins of this effect at the cellular level, we made whole cell voltage-clamp recordings from acutely isolated rat ventricular myocytes under controlled strain. Longitudinal stretch elicited noninactivating inward cationic currents that increased the action potential duration. These stretch-activated currents could be blocked by 100 microM Gd(3+) but not by octanol. The current-voltage relationship was nearly linear, with a reversal potential of approximately -6 mV in normal Tyrode solution. Current density varied with sarcomere length (SL) according to I (pA/pF) = 8.3 - 5.0 SL (microm). Repeated attempts to record single channel currents from stretch-activated ion channels failed, in accord with the absence of such data from the literature. The inability to record single channel currents may be a result of channels being located on internal membranes such as the T tubules or, possibly, inactivation of the channels by the mechanics of patch formation." @default.
- W2161662861 created "2016-06-24" @default.
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- W2161662861 date "2000-02-01" @default.
- W2161662861 modified "2023-10-02" @default.
- W2161662861 title "Stretch-activated whole cell currents in adult rat cardiac myocytes" @default.
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- W2161662861 doi "https://doi.org/10.1152/ajpheart.2000.278.2.h548" @default.
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