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- W2161680377 abstract "Abstract Nitrous acid (HNO 2 ) treated whole OX174 bacteriophage particles, but not treated OX174 DNA, were found to lose viability while being stored at 5°–8°C at pH 8.0. Thus, although the DNA moiety of the virus was the target for HNO 2 inactivation when infectivity was measured immediately after treatment, the protein moiety was implicated in loss of infectivity during storage following HNO 2 treatment. The viability of HNO 2 treated OX174 DNA depended on the age of the spheroplast culture used for the bioassay. Survival curves of treated DNA showed slower inactivation on newly prepared spheroplasts than on “old” ones. Some HNO 2 lesions which are normally sublethal are apparently lethal in older spheroplasts." @default.
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- W2161680377 date "1970-06-01" @default.
- W2161680377 modified "2023-09-27" @default.
- W2161680377 title "Inactivation of bacteriophage ØX174 by sublethal nitrous acid — Produced lesions" @default.
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- W2161680377 doi "https://doi.org/10.1016/0006-291x(70)90395-5" @default.
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