FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161735519> ?p ?o ?g. }

• W2161735519 endingPage "1705" @default.
• W2161735519 startingPage "1699" @default.
• W2161735519 abstract "Abstract Idiopathic myelofibrosis (IM) is characterized by the constitutive mobilization of CD34+ cells. IM peripheral blood (PB) CD34+ cells had a reduced cloning efficiency and a lower frequency of cobblestone areas compared with normal granulocyte colony-stimulating factor (G-CSF)-mobilized PB CD34+ cells. IM CD34+ cells engrafted nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice, demonstrating that they contain bone marrow (BM)-repopulating cells. G-CSF-mobilized CD34+ cells produced multiple hematopoietic lineages within the NOD/SCID mice with a predominance of CD19+ cells. By contrast, IM CD34+ cells produced predominantly CD33+ cells, increased numbers of CD41+ cells, but fewer CD19+ cells. Transcriptional clonality assays of the engrafted human IM cells demonstrated their clonal origin. CD34+ cells from one patient isolated prior to leukemic transformation were capable of generating acute leukemia in NOD/SCID mice. The engrafted human cells exhibited the same abnormal karyotype as primary cells in a portion of the population. These findings demonstrate that BM-repopulating cells and more differentiated progenitor cells are constitutively mobilized into the PB in IM, and that their differentiation program is abnormal. In addition, the NOD/SCID model may be useful in gaining an understanding of the events occurring during the transition of IM to acute leukemia. (Blood. 2005;105:1699-1705)" @default.
• W2161735519 created "2016-06-24" @default.
• W2161735519 creator A5006372952 @default.
• W2161735519 creator A5009179358 @default.
• W2161735519 creator A5011023599 @default.
• W2161735519 creator A5020634402 @default.
• W2161735519 creator A5028356813 @default.
• W2161735519 creator A5029836748 @default.
• W2161735519 creator A5033704013 @default.
• W2161735519 creator A5042381475 @default.
• W2161735519 creator A5054630704 @default.
• W2161735519 creator A5057579957 @default.
• W2161735519 creator A5058425712 @default.
• W2161735519 creator A5066107604 @default.
• W2161735519 creator A5066894053 @default.
• W2161735519 creator A5068146179 @default.
• W2161735519 creator A5089433535 @default.
• W2161735519 date "2005-02-15" @default.
• W2161735519 modified "2023-09-27" @default.
• W2161735519 title "The constitutive mobilization of bone marrow-repopulating cells into the peripheral blood in idiopathic myelofibrosis" @default.
• W2161735519 cites W1566936977 @default.
• W2161735519 cites W1605109493 @default.
• W2161735519 cites W1829333924 @default.
• W2161735519 cites W1967945335 @default.
• W2161735519 cites W1975798779 @default.
• W2161735519 cites W1993968364 @default.
• W2161735519 cites W1995188840 @default.
• W2161735519 cites W20043667 @default.
• W2161735519 cites W2005852731 @default.
• W2161735519 cites W2009886857 @default.
• W2161735519 cites W2015506962 @default.
• W2161735519 cites W2015997598 @default.
• W2161735519 cites W2022260878 @default.
• W2161735519 cites W2023365532 @default.
• W2161735519 cites W2023873491 @default.
• W2161735519 cites W2027927113 @default.
• W2161735519 cites W2029318538 @default.
• W2161735519 cites W2045977586 @default.
• W2161735519 cites W2050127987 @default.
• W2161735519 cites W2054130367 @default.
• W2161735519 cites W2069811721 @default.
• W2161735519 cites W2074148264 @default.
• W2161735519 cites W2095750011 @default.
• W2161735519 cites W2135230436 @default.
• W2161735519 cites W2169761717 @default.
• W2161735519 cites W2237667700 @default.
• W2161735519 cites W2302271358 @default.
• W2161735519 cites W2326795317 @default.
• W2161735519 cites W2331674116 @default.
• W2161735519 cites W2410401011 @default.
• W2161735519 cites W4239901736 @default.
• W2161735519 cites W98258303 @default.
• W2161735519 doi "https://doi.org/10.1182/blood-2004-06-2485" @default.
• W2161735519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15471948" @default.
• W2161735519 hasPublicationYear "2005" @default.
• W2161735519 type Work @default.
• W2161735519 sameAs 2161735519 @default.
• W2161735519 citedByCount "57" @default.
• W2161735519 countsByYear W21617355192012 @default.
• W2161735519 countsByYear W21617355192013 @default.
• W2161735519 countsByYear W21617355192014 @default.
• W2161735519 countsByYear W21617355192015 @default.
• W2161735519 countsByYear W21617355192016 @default.
• W2161735519 countsByYear W21617355192017 @default.
• W2161735519 countsByYear W21617355192020 @default.
• W2161735519 countsByYear W21617355192021 @default.
• W2161735519 countsByYear W21617355192023 @default.
• W2161735519 crossrefType "journal-article" @default.
• W2161735519 hasAuthorship W2161735519A5006372952 @default.
• W2161735519 hasAuthorship W2161735519A5009179358 @default.
• W2161735519 hasAuthorship W2161735519A5011023599 @default.
• W2161735519 hasAuthorship W2161735519A5020634402 @default.
• W2161735519 hasAuthorship W2161735519A5028356813 @default.
• W2161735519 hasAuthorship W2161735519A5029836748 @default.
• W2161735519 hasAuthorship W2161735519A5033704013 @default.
• W2161735519 hasAuthorship W2161735519A5042381475 @default.
• W2161735519 hasAuthorship W2161735519A5054630704 @default.
• W2161735519 hasAuthorship W2161735519A5057579957 @default.
• W2161735519 hasAuthorship W2161735519A5058425712 @default.
• W2161735519 hasAuthorship W2161735519A5066107604 @default.
• W2161735519 hasAuthorship W2161735519A5066894053 @default.
• W2161735519 hasAuthorship W2161735519A5068146179 @default.
• W2161735519 hasAuthorship W2161735519A5089433535 @default.
• W2161735519 hasBestOaLocation W21617355191 @default.
• W2161735519 hasConcept C10205521 @default.
• W2161735519 hasConcept C104317684 @default.
• W2161735519 hasConcept C109159458 @default.
• W2161735519 hasConcept C129374314 @default.
• W2161735519 hasConcept C131665280 @default.
• W2161735519 hasConcept C134018914 @default.
• W2161735519 hasConcept C147483822 @default.
• W2161735519 hasConcept C167672396 @default.
• W2161735519 hasConcept C201750760 @default.
• W2161735519 hasConcept C203014093 @default.
• W2161735519 hasConcept C2778957590 @default.
• W2161735519 hasConcept C2779468541 @default.
• W2161735519 hasConcept C2780007613 @default.
• W2161735519 hasConcept C2780076729 @default.

• next