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• W2161738006 abstract "ObjectiveTo examine the role of aerobic metabolism in fibroblasts from normal peritoneum and adhesions in the differential expression of extracellular matrix (ECM) and transforming growth factor-beta (TGF-β), an inflammatory cytokine that regulates ECM expression.DesignCell culture under normoxic and hypoxic conditions.SettingUniversity research laboratory.Patient(s)Human fibroblasts cultures from normal peritoneum and adhesions.Intervention(s)Exposure to dichloroacetic acid (DCA), which activates pyruvate dehydrogenase, for 24 hours under normal and hypoxic (2% O2) conditions.Main outcome measure(s)Multiplex reverse transcriptase polymerase chain reaction (RT/PCR) of type III collagen, fibronectin, TGF-β1, and β-actin was performed, with analysis of PCR-amplified products performed by densimetric analysis of gel bands using the National Institutes of Health Image analysis program.Result(s)DCA inhibited human peritoneal fibroblast and adhesion fibroblast TGF-β1 mRNA expression under normoxic and hypoxic conditions. DCA also markedly reduced fibronectin and type III collagen expression under hypoxic conditions in fibroblasts from normal peritoneum and adhesions.Conclusion(s)These observations provide further support for the suggestion that regulation of metabolic activity of peritoneal cells may provide a target for interventions designed to reduce postoperative adhesions." @default.
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• W2161738006 date "2003-05-01" @default.
• W2161738006 modified "2023-09-26" @default.
• W2161738006 title "Regulation of transforming growth factor-beta, type III collagen, and fibronectin by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions" @default.
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• W2161738006 doi "https://doi.org/10.1016/s0015-0282(03)00075-x" @default.
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