FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161739318> ?p ?o ?g. }

• W2161739318 endingPage "922" @default.
• W2161739318 startingPage "916" @default.
• W2161739318 abstract "Abstract The Hypermethylated in Cancer 1 (HIC1) gene encodes a zinc finger transcriptional repressor that cooperates with p53 to suppress cancer development. We and others recently showed that HIC1 is a transcriptional target of p53. To identify additional transcriptional regulators of HIC1, we screened a set of transcription factors for regulation of a human HIC1 promoter reporter. We found that E2F1 strongly activates the full-length HIC1 promoter reporter. Promoter deletions and mutations identified two E2F responsive elements in the HIC1 core promoter region. Moreover, in vivo binding of E2F1 to the HIC1 promoter was shown by chromatin immunoprecipitation assays in human TIG3 fibroblasts expressing tamoxifen-activated E2F1. In agreement, activation of E2F1 in TIG3-E2F1 cells markedly increased HIC1 expression. Interestingly, expression of E2F1 in the p53−/− hepatocellular carcinoma cell line Hep3B led to an increase of endogenous HIC1 mRNA, although bisulfite genomic sequencing of the HIC1 promoter revealed that the region bearing the two E2F1 binding sites is hypermethylated. In addition, endogenous E2F1 induced by etoposide treatment bound to the HIC1 promoter. Moreover, inhibition of E2F1 strongly reduced the expression of etoposide-induced HIC1. In conclusion, we identified HIC1 as novel E2F1 transcriptional target in DNA damage responses. (Mol Cancer Res 2009;7(6):916–22)" @default.
• W2161739318 created "2016-06-24" @default.
• W2161739318 creator A5000513493 @default.
• W2161739318 creator A5000852530 @default.
• W2161739318 creator A5001930745 @default.
• W2161739318 creator A5011822969 @default.
• W2161739318 creator A5020867690 @default.
• W2161739318 creator A5025224701 @default.
• W2161739318 creator A5038093792 @default.
• W2161739318 creator A5057084365 @default.
• W2161739318 creator A5063650567 @default.
• W2161739318 creator A5064044526 @default.
• W2161739318 creator A5073653373 @default.
• W2161739318 date "2009-06-01" @default.
• W2161739318 modified "2023-10-16" @default.
• W2161739318 title "The Tumor Suppressor Gene <i>Hypermethylated in Cancer 1</i> Is Transcriptionally Regulated by E2F1" @default.
• W2161739318 cites W1486152771 @default.
• W2161739318 cites W1762601366 @default.
• W2161739318 cites W1966971933 @default.
• W2161739318 cites W1969600675 @default.
• W2161739318 cites W1979935374 @default.
• W2161739318 cites W1982529039 @default.
• W2161739318 cites W1995979905 @default.
• W2161739318 cites W1997387658 @default.
• W2161739318 cites W2003825154 @default.
• W2161739318 cites W2019432938 @default.
• W2161739318 cites W2020288787 @default.
• W2161739318 cites W2022792299 @default.
• W2161739318 cites W2023283617 @default.
• W2161739318 cites W2029800672 @default.
• W2161739318 cites W2031753415 @default.
• W2161739318 cites W2052543236 @default.
• W2161739318 cites W2084576202 @default.
• W2161739318 cites W2086082161 @default.
• W2161739318 cites W2089456640 @default.
• W2161739318 cites W2093587470 @default.
• W2161739318 cites W2094646101 @default.
• W2161739318 cites W2102713631 @default.
• W2161739318 cites W2107277218 @default.
• W2161739318 cites W2114114824 @default.
• W2161739318 cites W2125538315 @default.
• W2161739318 cites W2143530087 @default.
• W2161739318 cites W2146453903 @default.
• W2161739318 cites W2153550523 @default.
• W2161739318 cites W2155972116 @default.
• W2161739318 cites W2157717197 @default.
• W2161739318 cites W2168289490 @default.
• W2161739318 cites W2321525112 @default.
• W2161739318 cites W3026147203 @default.
• W2161739318 doi "https://doi.org/10.1158/1541-7786.mcr-08-0359" @default.
• W2161739318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19491197" @default.
• W2161739318 hasPublicationYear "2009" @default.
• W2161739318 type Work @default.
• W2161739318 sameAs 2161739318 @default.
• W2161739318 citedByCount "24" @default.
• W2161739318 countsByYear W21617393182012 @default.
• W2161739318 countsByYear W21617393182013 @default.
• W2161739318 countsByYear W21617393182014 @default.
• W2161739318 countsByYear W21617393182015 @default.
• W2161739318 countsByYear W21617393182017 @default.
• W2161739318 countsByYear W21617393182019 @default.
• W2161739318 countsByYear W21617393182022 @default.
• W2161739318 crossrefType "journal-article" @default.
• W2161739318 hasAuthorship W2161739318A5000513493 @default.
• W2161739318 hasAuthorship W2161739318A5000852530 @default.
• W2161739318 hasAuthorship W2161739318A5001930745 @default.
• W2161739318 hasAuthorship W2161739318A5011822969 @default.
• W2161739318 hasAuthorship W2161739318A5020867690 @default.
• W2161739318 hasAuthorship W2161739318A5025224701 @default.
• W2161739318 hasAuthorship W2161739318A5038093792 @default.
• W2161739318 hasAuthorship W2161739318A5057084365 @default.
• W2161739318 hasAuthorship W2161739318A5063650567 @default.
• W2161739318 hasAuthorship W2161739318A5064044526 @default.
• W2161739318 hasAuthorship W2161739318A5073653373 @default.
• W2161739318 hasBestOaLocation W21617393181 @default.
• W2161739318 hasConcept C101762097 @default.
• W2161739318 hasConcept C104317684 @default.
• W2161739318 hasConcept C119056186 @default.
• W2161739318 hasConcept C134320426 @default.
• W2161739318 hasConcept C150194340 @default.
• W2161739318 hasConcept C153911025 @default.
• W2161739318 hasConcept C158448853 @default.
• W2161739318 hasConcept C183022183 @default.
• W2161739318 hasConcept C502942594 @default.
• W2161739318 hasConcept C54355233 @default.
• W2161739318 hasConcept C86339819 @default.
• W2161739318 hasConcept C86803240 @default.
• W2161739318 hasConceptScore W2161739318C101762097 @default.
• W2161739318 hasConceptScore W2161739318C104317684 @default.
• W2161739318 hasConceptScore W2161739318C119056186 @default.
• W2161739318 hasConceptScore W2161739318C134320426 @default.
• W2161739318 hasConceptScore W2161739318C150194340 @default.
• W2161739318 hasConceptScore W2161739318C153911025 @default.
• W2161739318 hasConceptScore W2161739318C158448853 @default.
• W2161739318 hasConceptScore W2161739318C183022183 @default.
• W2161739318 hasConceptScore W2161739318C502942594 @default.
• W2161739318 hasConceptScore W2161739318C54355233 @default.
• W2161739318 hasConceptScore W2161739318C86339819 @default.

• next