FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161750455> ?p ?o ?g. }

• W2161750455 endingPage "1476" @default.
• W2161750455 startingPage "1467" @default.
• W2161750455 abstract "Objectives. In JIA there is an unmet need for biomarkers with which to identify patients who will respond well to MTX. The aim of this study was to define the prognostic value of baseline serum proteins and clinical variables in response to MTX to help inform the clinician at time of diagnosis whether the patient is likely to respond well to MTX. Methods. JIA patients were recruited into the Childhood Arthritis Response to Medication Study (CHARMS). Clinical data and venous blood were collected before administration of MTX and at follow-up. MRP8/14 and inflammatory cytokines were measured by ELISA and multiplex immunoassay, respectively. CRP and ESR were measured as part of routine clinical assessment. To explore which baseline factors might predict successful treatment, binary logistic regression models were fitted for outcome. Results. High disease activity (high serum MRP8/14, active joint count or physician's score) pre-MTX was observed in a subgroup of patients with a better response to therapy. In a multivariable analysis, after accounting for MRP8/14 at baseline, no other factors were independently significantly associated with outcome. Patients with baseline MRP8/14 >3000 ng/ml were more likely to respond to MTX at ACR50 or better: odds ratio 16.07 (95% CI 2.00, 129.3). Conclusion. We have demonstrated that high levels of baseline serum MRP8/14 have prognostic value in predicting a subgroup of patients whose arthritis will improve on MTX. Routine collection of serum prior to the start of medication would be a valuable step in collaborative validation of such biomarkers." @default.
• W2161750455 created "2016-06-24" @default.
• W2161750455 creator A5005583949 @default.
• W2161750455 creator A5026939249 @default.
• W2161750455 creator A5037338479 @default.
• W2161750455 creator A5058295415 @default.
• W2161750455 creator A5063516762 @default.
• W2161750455 creator A5076400177 @default.
• W2161750455 creator A5085622358 @default.
• W2161750455 creator A5090673860 @default.
• W2161750455 date "2013-04-25" @default.
• W2161750455 modified "2023-09-30" @default.
• W2161750455 title "A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/14 protein" @default.
• W2161750455 cites W1969936299 @default.
• W2161750455 cites W1973827444 @default.
• W2161750455 cites W1982099030 @default.
• W2161750455 cites W1999645262 @default.
• W2161750455 cites W2014383245 @default.
• W2161750455 cites W2024714476 @default.
• W2161750455 cites W2044015582 @default.
• W2161750455 cites W2062010958 @default.
• W2161750455 cites W2065293032 @default.
• W2161750455 cites W2066990030 @default.
• W2161750455 cites W2073700972 @default.
• W2161750455 cites W2076961991 @default.
• W2161750455 cites W2077112110 @default.
• W2161750455 cites W2079280291 @default.
• W2161750455 cites W2091075158 @default.
• W2161750455 cites W2101040039 @default.
• W2161750455 cites W2106320555 @default.
• W2161750455 cites W2113202860 @default.
• W2161750455 cites W2113398985 @default.
• W2161750455 cites W2118217628 @default.
• W2161750455 cites W2133984258 @default.
• W2161750455 cites W2140870177 @default.
• W2161750455 cites W2148177365 @default.
• W2161750455 cites W2153714977 @default.
• W2161750455 cites W2154552358 @default.
• W2161750455 cites W2156049013 @default.
• W2161750455 cites W2159111033 @default.
• W2161750455 cites W2161305892 @default.
• W2161750455 cites W2166106092 @default.
• W2161750455 cites W2167790577 @default.
• W2161750455 cites W4230379729 @default.
• W2161750455 doi "https://doi.org/10.1093/rheumatology/ket152" @default.
• W2161750455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23620557" @default.
• W2161750455 hasPublicationYear "2013" @default.
• W2161750455 type Work @default.
• W2161750455 sameAs 2161750455 @default.
• W2161750455 citedByCount "76" @default.
• W2161750455 countsByYear W21617504552013 @default.
• W2161750455 countsByYear W21617504552014 @default.
• W2161750455 countsByYear W21617504552015 @default.
• W2161750455 countsByYear W21617504552016 @default.
• W2161750455 countsByYear W21617504552017 @default.
• W2161750455 countsByYear W21617504552018 @default.
• W2161750455 countsByYear W21617504552019 @default.
• W2161750455 countsByYear W21617504552020 @default.
• W2161750455 countsByYear W21617504552021 @default.
• W2161750455 countsByYear W21617504552022 @default.
• W2161750455 countsByYear W21617504552023 @default.
• W2161750455 crossrefType "journal-article" @default.
• W2161750455 hasAuthorship W2161750455A5005583949 @default.
• W2161750455 hasAuthorship W2161750455A5026939249 @default.
• W2161750455 hasAuthorship W2161750455A5037338479 @default.
• W2161750455 hasAuthorship W2161750455A5058295415 @default.
• W2161750455 hasAuthorship W2161750455A5063516762 @default.
• W2161750455 hasAuthorship W2161750455A5076400177 @default.
• W2161750455 hasAuthorship W2161750455A5085622358 @default.
• W2161750455 hasAuthorship W2161750455A5090673860 @default.
• W2161750455 hasBestOaLocation W21617504551 @default.
• W2161750455 hasConcept C126322002 @default.
• W2161750455 hasConcept C151956035 @default.
• W2161750455 hasConcept C156957248 @default.
• W2161750455 hasConcept C185592680 @default.
• W2161750455 hasConcept C187960798 @default.
• W2161750455 hasConcept C203014093 @default.
• W2161750455 hasConcept C2776821229 @default.
• W2161750455 hasConcept C2777077863 @default.
• W2161750455 hasConcept C2777575956 @default.
• W2161750455 hasConcept C2781059491 @default.
• W2161750455 hasConcept C2781197716 @default.
• W2161750455 hasConcept C44249647 @default.
• W2161750455 hasConcept C55493867 @default.
• W2161750455 hasConcept C71924100 @default.
• W2161750455 hasConceptScore W2161750455C126322002 @default.
• W2161750455 hasConceptScore W2161750455C151956035 @default.
• W2161750455 hasConceptScore W2161750455C156957248 @default.
• W2161750455 hasConceptScore W2161750455C185592680 @default.
• W2161750455 hasConceptScore W2161750455C187960798 @default.
• W2161750455 hasConceptScore W2161750455C203014093 @default.
• W2161750455 hasConceptScore W2161750455C2776821229 @default.
• W2161750455 hasConceptScore W2161750455C2777077863 @default.
• W2161750455 hasConceptScore W2161750455C2777575956 @default.
• W2161750455 hasConceptScore W2161750455C2781059491 @default.
• W2161750455 hasConceptScore W2161750455C2781197716 @default.
• W2161750455 hasConceptScore W2161750455C44249647 @default.
• W2161750455 hasConceptScore W2161750455C55493867 @default.

• next