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- W2161757100 abstract "Since the proposal that nitric oxide acts as an intercellular signalling molecule in the nervous system, a large number of studies have been carried out to determine its functions in neural tissue. In this study, neuronal nitric oxide synthase using the highly specific polyclonal nature of an antibody is observed mainly in laminae I-II i , lamina X and in the intermediolateral cell column of the thoraco-lumbar spinal cord. The distribution of neuronal nitric oxide synthase was confirmed and extended the work done in previous studies. Distinct concentrations of neuronal nitric oxide synthase expressing small to medium sized neurones were seen in two bands: one in lamina I and the second in lamina II i . It is suggested that these neurones are probably Islet type interneurones and could be inhibitory interneurones. Therefore, based on the observations of nitric oxide synthase containing neurones in laminae I-II, laminae IV-V and lamina X, it suggests that nitric oxide is involved in nociception. Ratlar›n Omuriliinde Nitrik Oksit Enziminin Da¤›l›m› Ozet: Nitrik oksit'in sinir sisteminde hucreleraras› uyar›lar› iletiminde rol alan molekul olduu kabulunden itibaren, bunun sinirsel dokulardaki fonksiyonlar›n› tesbit etmek amac›yla cok say›da cal›flmalar yap›lm›flt›r. Bu cal›flmada, poliklonal doal antikorlara oldukca yuksek oranda duyarl›l›k gosteren antikorun kullan›m›yla, noronal nitrik oksit sentez bolgelerinin esas olarak, thoraco-lumbal omuriliin lamina I, IIi, X ve intermediolateral kornuda lokalize olduu gozlenmifltir. Bu sonuclar daha once yap›lan cal›flmalarla paralellik gosterdii gibi, baz› ilave yeni bilgiler de salam›flt›r. Noronal nitrik oksit sentez bolgelerinin kucukten orta hacime kadar deiflen buyuklukte ve belirgin bir flekilde olan noronlar› lamina I ve internal lamina IIi' de iki ayr› bant fleklinde gozlenmifltir. Bu noronlar›n Islet veya inhibitor tipte internoronlar olabilecei duflunulmektedir. Boylece, lamina I-II, IV-V ve lamina X'deki lokalize olan nitrik oksit sentez bolgelerinin bulunduu noronlara gore nitrik oksitin ar› duyusunun iletiminde rol oynad›¤› san›lmaktad›r." @default.
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- W2161757100 date "2001-03-22" @default.
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- W2161757100 title "The Distribution of Nitric Oxide Synthase in the Rat Spinal Cord" @default.
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