FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161768559> ?p ?o ?g. }

• W2161768559 endingPage "1646" @default.
• W2161768559 startingPage "1640" @default.
• W2161768559 abstract "<h3>Background</h3> Genetic variants within genes involved in fibrillogenesis have previously been implicated in anterior cruciate ligament (ACL) injury susceptibility. Proteoglycans also have important functions in fibrillogenesis and maintaining the structural integrity of ligaments. Genes encoding proteoglycans are plausible candidates to be investigated for associations with ACL injury susceptibility; polymorphisms within genes encoding the proteoglycans aggrecan (<i>ACAN</i>), biglycan (<i>BGN</i>), decorin (<i>DCN</i>), fibromodulin (<i>FMOD</i>) and lumican (<i>LUM</i>) were examined. <h3>Methods</h3> A case–control genetic association study was conducted. 227 participants with surgically diagnosed ACL ruptures (ACL group) and 234 controls without any history of ACL injury were genotyped for 10 polymorphisms in 5 proteoglycan genes. Inferred haplotypes were constructed for specific regions. <h3>Results</h3> The G allele of <i>ACAN</i> rs1516797 was significantly under-represented in the controls (p=0.024; OR=0.72; 95% CI 0.55 to 0.96) compared with the ACL group. For <i>DCN</i> rs516115, the GG genotype was significantly over-represented in female controls (p=0.015; OR=9.231; 95%CI 1.16 to 73.01) compared with the ACL group and the AA genotype was significantly under-represented in controls (p=0.013; OR=0.33; 95% CI 0.14 to 0.78) compared with the female non-contact ACL injury subgroup. Haplotype analyses implicated regions overlapping <i>ACAN</i> (rs2351491 C>T-rs1042631 T>C-rs1516797 T>G), <i>BGN</i> (rs1126499 C>T-rs1042103 G>A) and <i>LUM</i>-<i>DCN</i> (rs2268578 T>C-rs13312816 A>T-rs516115 A>G) in ACL injury susceptibility. <h3>Conclusions</h3> These independent associations and haplotype analyses suggest that regions within <i>ACAN</i>, <i>BGN</i>, <i>DCN</i> and a region spanning <i>LUM</i>–<i>DCN</i> are associated with ACL injury susceptibility. Taking into account the functions of these genes, it is reasonable to propose that genetic sequence variability within the genes encoding proteoglycans may potentially modulate the ligament fibril properties." @default.
• W2161768559 created "2016-06-24" @default.
• W2161768559 creator A5002088480 @default.
• W2161768559 creator A5054473405 @default.
• W2161768559 creator A5055137419 @default.
• W2161768559 creator A5063402986 @default.
• W2161768559 creator A5083677428 @default.
• W2161768559 creator A5084263877 @default.
• W2161768559 creator A5087015207 @default.
• W2161768559 date "2014-02-19" @default.
• W2161768559 modified "2023-10-16" @default.
• W2161768559 title "Genes encoding proteoglycans are associated with the risk of anterior cruciate ligament ruptures" @default.
• W2161768559 cites W1525953672 @default.
• W2161768559 cites W1544527238 @default.
• W2161768559 cites W1749934497 @default.
• W2161768559 cites W1920414787 @default.
• W2161768559 cites W1926949618 @default.
• W2161768559 cites W1973516953 @default.
• W2161768559 cites W1976566500 @default.
• W2161768559 cites W1984401784 @default.
• W2161768559 cites W1986728673 @default.
• W2161768559 cites W1988176578 @default.
• W2161768559 cites W1996332681 @default.
• W2161768559 cites W1998957301 @default.
• W2161768559 cites W2002566214 @default.
• W2161768559 cites W2009298572 @default.
• W2161768559 cites W2010501457 @default.
• W2161768559 cites W2014813076 @default.
• W2161768559 cites W2017271806 @default.
• W2161768559 cites W2020330132 @default.
• W2161768559 cites W2021925491 @default.
• W2161768559 cites W2022583200 @default.
• W2161768559 cites W2026550755 @default.
• W2161768559 cites W2029197450 @default.
• W2161768559 cites W2039983717 @default.
• W2161768559 cites W2040707712 @default.
• W2161768559 cites W2042738496 @default.
• W2161768559 cites W2043746933 @default.
• W2161768559 cites W2052801322 @default.
• W2161768559 cites W2054838359 @default.
• W2161768559 cites W2055972025 @default.
• W2161768559 cites W2058417962 @default.
• W2161768559 cites W2065158619 @default.
• W2161768559 cites W2068121966 @default.
• W2161768559 cites W2068616521 @default.
• W2161768559 cites W2070013317 @default.
• W2161768559 cites W2088340988 @default.
• W2161768559 cites W2094260121 @default.
• W2161768559 cites W2103259282 @default.
• W2161768559 cites W2105199928 @default.
• W2161768559 cites W2106704887 @default.
• W2161768559 cites W2107283165 @default.
• W2161768559 cites W2109037249 @default.
• W2161768559 cites W2118356843 @default.
• W2161768559 cites W2129849931 @default.
• W2161768559 cites W2130548277 @default.
• W2161768559 cites W2131020830 @default.
• W2161768559 cites W2131561239 @default.
• W2161768559 cites W2131687641 @default.
• W2161768559 cites W2132797493 @default.
• W2161768559 cites W2141265124 @default.
• W2161768559 cites W2145632357 @default.
• W2161768559 cites W2146027763 @default.
• W2161768559 cites W2150552011 @default.
• W2161768559 cites W2152229306 @default.
• W2161768559 cites W2157172235 @default.
• W2161768559 cites W2157589122 @default.
• W2161768559 cites W2171324071 @default.
• W2161768559 cites W2179304382 @default.
• W2161768559 cites W3161473256 @default.
• W2161768559 cites W318927918 @default.
• W2161768559 doi "https://doi.org/10.1136/bjsports-2013-093201" @default.
• W2161768559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24552666" @default.
• W2161768559 hasPublicationYear "2014" @default.
• W2161768559 type Work @default.
• W2161768559 sameAs 2161768559 @default.
• W2161768559 citedByCount "54" @default.
• W2161768559 countsByYear W21617685592014 @default.
• W2161768559 countsByYear W21617685592015 @default.
• W2161768559 countsByYear W21617685592016 @default.
• W2161768559 countsByYear W21617685592017 @default.
• W2161768559 countsByYear W21617685592018 @default.
• W2161768559 countsByYear W21617685592019 @default.
• W2161768559 countsByYear W21617685592020 @default.
• W2161768559 countsByYear W21617685592021 @default.
• W2161768559 countsByYear W21617685592022 @default.
• W2161768559 countsByYear W21617685592023 @default.
• W2161768559 crossrefType "journal-article" @default.
• W2161768559 hasAuthorship W2161768559A5002088480 @default.
• W2161768559 hasAuthorship W2161768559A5054473405 @default.
• W2161768559 hasAuthorship W2161768559A5055137419 @default.
• W2161768559 hasAuthorship W2161768559A5063402986 @default.
• W2161768559 hasAuthorship W2161768559A5083677428 @default.
• W2161768559 hasAuthorship W2161768559A5084263877 @default.
• W2161768559 hasAuthorship W2161768559A5087015207 @default.
• W2161768559 hasConcept C104317684 @default.
• W2161768559 hasConcept C105702510 @default.
• W2161768559 hasConcept C126322002 @default.

• next