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• W2161771887 endingPage "183" @default.
• W2161771887 startingPage "175" @default.
• W2161771887 abstract "Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by bidirectional or polymorphic ventricular arrhythmias under conditions of increased sympathetic activity in young patients with structurally normal hearts. Patients with CPVT are at high risk of developing life-threatening ventricular arrhythmias when untreated. A wide variety of arrhythmic event rates on conventional therapy, with β-blockers as the cornerstone, has been reported. Here, we systematically review all available studies describing the efficacy of β-blocker therapy for prevention of arrhythmic events in CPVT. Because of heterogeneity between the studies, a random-effects meta-analysis model was used to assess the efficacy of β-blocker therapy in preventing any arrhythmic event [syncope, aborted cardiac arrest (ACA), and sudden cardiac death (SCD)], near-fatal arrhythmic events (ACA and SCD), and fatal arrhythmic events. Eleven studies including 403 patients, of whom 354 (88%) had a β-blocker prescribed, were identified. Mean follow-up ranged from 20 months to 8 years. Estimated 8-year arrhythmic, near-fatal, and fatal event rates were 37.2% [95% confidence interval (CI): 16.6–57.7], 15.3% (95% CI: 7.4–23.3), and 6.4% (95% CI: 3.2–9.6), respectively. In addition, we review the recent developments in alternate chronic treatment options for CPVT patients, including calcium channel blockers, flecainide, left cardiac sympathetic denervation, and implantable cardioverter defibrillators. A new treatment strategy is proposed, including a stepwise addition of the alternate treatment options to β-blockers in patients who do not respond sufficiently to this first-line therapy. Finally, future developments in chronic treatment options and acute treatment options of ventricular arrhythmias are discussed." @default.
• W2161771887 created "2016-06-24" @default.
• W2161771887 creator A5002151074 @default.
• W2161771887 creator A5020601629 @default.
• W2161771887 creator A5051056050 @default.
• W2161771887 date "2011-09-04" @default.
• W2161771887 modified "2023-10-17" @default.
• W2161771887 title "Therapeutic approach for patients with catecholaminergic polymorphic ventricular tachycardia: state of the art and future developments" @default.
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• W2161771887 doi "https://doi.org/10.1093/europace/eur277" @default.
• W2161771887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21893508" @default.
• W2161771887 hasPublicationYear "2011" @default.
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