FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161776461> ?p ?o ?g. }

• W2161776461 endingPage "1070" @default.
• W2161776461 startingPage "1059" @default.
• W2161776461 abstract "Abstract Purinergic ionotropic P2X receptors are a family of cation-permeable channels that bind extracellular adenosine 5′-triphosphate. In particular, convergent lines of evidence have recently highlighted P2X4 receptors as a potentially critical target in the regulation of multiple nervous and behavioural functions, including pain, neuroendocrine regulation and hippocampal plasticity. Nevertheless, the role of the P2X4 receptor in behavioural organization remains poorly investigated. To study the effects of P2X4 activation, we tested the acute effects of its potent positive allosteric modulator ivermectin (IVM, 2.5–10 mg/kg i.p.) on a broad set of paradigms capturing complementary aspects of perceptual, emotional and cognitive regulation in mice. In a novel open field, IVM did not induce significant changes in locomotor activity, but increased the time spent in the peripheral zone. In contrast, IVM produced anxiolytic-like effects in the elevated plus maze and marble burying tasks, as well as depression-like behaviours in the tail-suspension and forced swim tests. The agent induced no significant behavioural changes in the conditioned place preference test and in the novel object recognition task. Finally, the drug induced a dose-dependent decrease in sensorimotor gating, as assessed by pre-pulse inhibition (PPI) of the acoustic startle reflex. In P2X4 knockout mice, the effects of IVM in the open field and elevated plus maze were similar to those observed in wild type mice; conversely, the drug significantly increased startle amplitude and failed to reduce PPI. Taken together, these results suggest that P2X4 receptors may play a role in the regulation of sensorimotor gating." @default.
• W2161776461 created "2016-06-24" @default.
• W2161776461 creator A5002462952 @default.
• W2161776461 creator A5016253604 @default.
• W2161776461 creator A5018119581 @default.
• W2161776461 creator A5023856434 @default.
• W2161776461 creator A5041043150 @default.
• W2161776461 creator A5046921350 @default.
• W2161776461 creator A5049271693 @default.
• W2161776461 creator A5049638521 @default.
• W2161776461 creator A5071431222 @default.
• W2161776461 date "2013-06-01" @default.
• W2161776461 modified "2023-10-14" @default.
• W2161776461 title "Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin" @default.
• W2161776461 cites W1480157153 @default.
• W2161776461 cites W1490568823 @default.
• W2161776461 cites W1529221656 @default.
• W2161776461 cites W1699660695 @default.
• W2161776461 cites W1817985333 @default.
• W2161776461 cites W1926752139 @default.
• W2161776461 cites W1959467500 @default.
• W2161776461 cites W1964678173 @default.
• W2161776461 cites W1964805904 @default.
• W2161776461 cites W1966037459 @default.
• W2161776461 cites W1966775719 @default.
• W2161776461 cites W1967648832 @default.
• W2161776461 cites W1968123967 @default.
• W2161776461 cites W1968638036 @default.
• W2161776461 cites W1971786072 @default.
• W2161776461 cites W1975087532 @default.
• W2161776461 cites W1978373371 @default.
• W2161776461 cites W1979420282 @default.
• W2161776461 cites W1984025105 @default.
• W2161776461 cites W1990354407 @default.
• W2161776461 cites W1995984309 @default.
• W2161776461 cites W1998364591 @default.
• W2161776461 cites W2000695431 @default.
• W2161776461 cites W2000720249 @default.
• W2161776461 cites W2004111769 @default.
• W2161776461 cites W2015334789 @default.
• W2161776461 cites W2018934217 @default.
• W2161776461 cites W2030424258 @default.
• W2161776461 cites W2031434196 @default.
• W2161776461 cites W2032273418 @default.
• W2161776461 cites W2033948582 @default.
• W2161776461 cites W2034788081 @default.
• W2161776461 cites W2055688568 @default.
• W2161776461 cites W2055920458 @default.
• W2161776461 cites W2057264061 @default.
• W2161776461 cites W2062679693 @default.
• W2161776461 cites W2065336052 @default.
• W2161776461 cites W2075609074 @default.
• W2161776461 cites W2090498136 @default.
• W2161776461 cites W2103659596 @default.
• W2161776461 cites W2104419150 @default.
• W2161776461 cites W2111765237 @default.
• W2161776461 cites W2111863516 @default.
• W2161776461 cites W2129411418 @default.
• W2161776461 cites W2131378880 @default.
• W2161776461 cites W2136344894 @default.
• W2161776461 cites W2144391400 @default.
• W2161776461 cites W2149040036 @default.
• W2161776461 cites W2154662447 @default.
• W2161776461 cites W2156346381 @default.
• W2161776461 cites W2161355492 @default.
• W2161776461 cites W2162336413 @default.
• W2161776461 cites W2163692939 @default.
• W2161776461 cites W2169784685 @default.
• W2161776461 cites W2170480117 @default.
• W2161776461 cites W3022052974 @default.
• W2161776461 cites W4237397855 @default.
• W2161776461 doi "https://doi.org/10.1017/s1461145712000909" @default.
• W2161776461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3593990" @default.
• W2161776461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23174033" @default.
• W2161776461 hasPublicationYear "2013" @default.
• W2161776461 type Work @default.
• W2161776461 sameAs 2161776461 @default.
• W2161776461 citedByCount "36" @default.
• W2161776461 countsByYear W21617764612013 @default.
• W2161776461 countsByYear W21617764612014 @default.
• W2161776461 countsByYear W21617764612015 @default.
• W2161776461 countsByYear W21617764612016 @default.
• W2161776461 countsByYear W21617764612017 @default.
• W2161776461 countsByYear W21617764612018 @default.
• W2161776461 countsByYear W21617764612019 @default.
• W2161776461 countsByYear W21617764612020 @default.
• W2161776461 countsByYear W21617764612021 @default.
• W2161776461 countsByYear W21617764612022 @default.
• W2161776461 countsByYear W21617764612023 @default.
• W2161776461 crossrefType "journal-article" @default.
• W2161776461 hasAuthorship W2161776461A5002462952 @default.
• W2161776461 hasAuthorship W2161776461A5016253604 @default.
• W2161776461 hasAuthorship W2161776461A5018119581 @default.
• W2161776461 hasAuthorship W2161776461A5023856434 @default.
• W2161776461 hasAuthorship W2161776461A5041043150 @default.
• W2161776461 hasAuthorship W2161776461A5046921350 @default.
• W2161776461 hasAuthorship W2161776461A5049271693 @default.
• W2161776461 hasAuthorship W2161776461A5049638521 @default.

• next