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- W2161778052 abstract "Hepatic stellate cells (HSC) are localized in Disse space of the hepatic sinusoid. Normally, The quiescent HSC produce the connective tissue proteins of the hepatic stroma and it is the principal storage of vitamin A. However, after a noxious stimulus the HSC is able to modify its phenotype and it is known as HSC activation. This activation is characterized by the increased expression of collagen type I that eventually lead to fibrosis or cirrhosis. The cell activation, directly depend of the next cytokines: PDGF-BB, TGF-β1 and TNF-α. The cytokines are produced by Kuppfer cells and HSC. They act trough the activation of several transcription factor proteins localized inside of HSC, that bind at the promoter level and regulate the gene expression of α-collagen 1(I) and α-collagen 2(I)." @default.
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- W2161778052 date "2005-01-01" @default.
- W2161778052 modified "2023-09-26" @default.
- W2161778052 title "Mecanismos moleculares de la regulación transcripcional de colágena α1(I) por las células estelares hepáticas" @default.
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