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• W2161827453 startingPage "e23436" @default.
• W2161827453 abstract "Genetic comparison between human embryonic stem cells and induced pluripotent stem cells has been hampered by genetic variation. To solve this problem, we have developed an isogenic system that allows direct comparison of induced pluripotent stem cells (hiPSCs) to their genetically matched human embryonic stem cells (hESCs). We show that hiPSCs have a highly similar transcriptome to hESCs. Global transcriptional profiling identified 102–154 genes (>2 fold) that showed a difference between isogenic hiPSCs and hESCs. A stringent analysis identified NNAT as a key imprinted gene that was dysregulated in hiPSCs. Furthermore, a disproportionate number of X-chromosome localized genes were over-expressed in female hiPSCs. Our results indicate that despite a remarkably close transcriptome to hESCs, isogenic hiPSCs have alterations in imprinting and regulation of X-chromosome genes." @default.
• W2161827453 created "2016-06-24" @default.
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• W2161827453 creator A5035681339 @default.
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• W2161827453 date "2011-10-12" @default.
• W2161827453 modified "2023-10-18" @default.
• W2161827453 title "Suppression of the Imprinted Gene NNAT and X-Chromosome Gene Activation in Isogenic Human iPS Cells" @default.
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• W2161827453 doi "https://doi.org/10.1371/journal.pone.0023436" @default.
• W2161827453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3192059" @default.
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