Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161832141> ?p ?o ?g. }
- W2161832141 endingPage "6902" @default.
- W2161832141 startingPage "6888" @default.
- W2161832141 abstract "The dsRNA-dependent protein kinase (PKR) is considered to play a key role in interferon-mediated host defense against viral infection and conceivably malignant transformation. To investigate further the mechanisms of PKR-induced growth inhibition, we have developed tetracycline-inducible murine cell lines that express wild-type PKR or a catalytically inactive PKR variant, PKRdelta6. Following induction, the growth of the wild-type PKR-expressing cells was similar to that of cells transfected with vector alone, while cells expressing PKRdelta6 became malignantly transformed. Significantly, treatment with dsRNA caused the wild-type PKR-overexpressing cells to undergo programed cell death while, conversely, cells expressing PKRdelta6 were completely resistant. Our studies demonstrated that activation of PKR induces the expression of members of the tumor necrosis factor receptor (TNFR) family, including Fas (CD95/Apo-1) and pro-apopotic Bax. In contrast, transcripts representing Fas, TNFR-1, FADD (Fas-associated death domain), FLICE, Bad and Bax were ablated in cells expressing PKRdelta6. The involvement of the death receptors in PKR-induced apoptosis was underscored by demonstrating that murine fibroblasts lacking FADD were almost completely resistant to dsRNA-mediated cell death. Thus, PKR, a key cellular target for viral repression, is a receptor/inducer for the induction of pro-apoptotic genes by dsRNA and probably functions in interferon-mediated host defense to trigger cell death in response to virus infection and perhaps tumorigenesis." @default.
- W2161832141 created "2016-06-24" @default.
- W2161832141 creator A5000800493 @default.
- W2161832141 creator A5013970928 @default.
- W2161832141 creator A5032428730 @default.
- W2161832141 creator A5050204036 @default.
- W2161832141 creator A5050436106 @default.
- W2161832141 creator A5079069209 @default.
- W2161832141 date "1998-12-01" @default.
- W2161832141 modified "2023-09-27" @default.
- W2161832141 title "Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling" @default.
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