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- W2161883289 endingPage "84" @default.
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- W2161883289 abstract "This paper reviews recent strategies used for increasing specific yield and productivity in high cell density cultures. High cell density cultures offer an efficient means for the economical production of recombinant proteins. However, there are still some challenges associated with high cell density cultivation (HCDC) techniques. A variety of strategies in several aspects including host design consideration, tuning recombinant protein expression, medium composition, growth methodologies, and even control and analysis of the process have been successfully employed by biotechnologists to increase yield in high cell density cultures. Although most researches have focused on Escherichia coli, other microorganisms have the potential to be grown at high density and need further investigation. In recent years, information on physiological changes of hosts during different phases of cultivation derived from functional genomics, transcriptomics and proteomics is being used to overcome the obstacles encountered in high cell density cultivation and hence increase productivity." @default.
- W2161883289 created "2016-06-24" @default.
- W2161883289 creator A5003253049 @default.
- W2161883289 creator A5021665428 @default.
- W2161883289 creator A5057931056 @default.
- W2161883289 creator A5072309089 @default.
- W2161883289 date "2008-04-01" @default.
- W2161883289 modified "2023-09-27" @default.
- W2161883289 title "Recent Advances in High Cell Density Cultivation for Production of Recombinant Protein" @default.
- W2161883289 cites W1243063173 @default.
- W2161883289 cites W139260636 @default.
- W2161883289 cites W1481913710 @default.
- W2161883289 cites W1482367909 @default.
- W2161883289 cites W1498386115 @default.
- W2161883289 cites W1504774114 @default.
- W2161883289 cites W150863655 @default.
- W2161883289 cites W152461987 @default.
- W2161883289 cites W156929183 @default.
- W2161883289 cites W166069334 @default.
- W2161883289 cites W1869174880 @default.
- W2161883289 cites W1963626107 @default.
- W2161883289 cites W1964569658 @default.
- W2161883289 cites W1965146535 @default.
- W2161883289 cites W1965338375 @default.
- W2161883289 cites W1969282686 @default.
- W2161883289 cites W1969622794 @default.
- W2161883289 cites W1969877186 @default.
- W2161883289 cites W1971071371 @default.
- W2161883289 cites W1971402315 @default.
- W2161883289 cites W197246024 @default.
- W2161883289 cites W1973091850 @default.
- W2161883289 cites W1974935992 @default.
- W2161883289 cites W1976482993 @default.
- W2161883289 cites W1979221688 @default.
- W2161883289 cites W1981616269 @default.
- W2161883289 cites W1982928218 @default.
- W2161883289 cites W1983950401 @default.
- W2161883289 cites W1984275481 @default.
- W2161883289 cites W1984613385 @default.
- W2161883289 cites W1985920238 @default.
- W2161883289 cites W1986555817 @default.
- W2161883289 cites W1990235837 @default.
- W2161883289 cites W1990744940 @default.
- W2161883289 cites W1992036123 @default.
- W2161883289 cites W1992394885 @default.
- W2161883289 cites W1995305196 @default.
- W2161883289 cites W1996380733 @default.
- W2161883289 cites W1997560717 @default.
- W2161883289 cites W1999414455 @default.
- W2161883289 cites W2001313873 @default.
- W2161883289 cites W2001612831 @default.
- W2161883289 cites W2002006497 @default.
- W2161883289 cites W2003547042 @default.
- W2161883289 cites W2006021138 @default.
- W2161883289 cites W2007486993 @default.
- W2161883289 cites W2010466066 @default.
- W2161883289 cites W2011971293 @default.
- W2161883289 cites W2012164540 @default.
- W2161883289 cites W2012356076 @default.
- W2161883289 cites W2012879795 @default.
- W2161883289 cites W2013099371 @default.
- W2161883289 cites W2014213448 @default.
- W2161883289 cites W2014435953 @default.
- W2161883289 cites W2014846113 @default.
- W2161883289 cites W2014971588 @default.
- W2161883289 cites W2015198573 @default.
- W2161883289 cites W2015433753 @default.
- W2161883289 cites W2016997209 @default.
- W2161883289 cites W2017030361 @default.
- W2161883289 cites W2017526934 @default.
- W2161883289 cites W2018261313 @default.
- W2161883289 cites W2023083550 @default.
- W2161883289 cites W2023171502 @default.
- W2161883289 cites W2024130504 @default.
- W2161883289 cites W2024185256 @default.
- W2161883289 cites W2024709249 @default.
- W2161883289 cites W2025086931 @default.
- W2161883289 cites W2025382626 @default.
- W2161883289 cites W2027549853 @default.
- W2161883289 cites W2028131776 @default.
- W2161883289 cites W2028546398 @default.
- W2161883289 cites W2028644275 @default.
- W2161883289 cites W2032513246 @default.
- W2161883289 cites W2032774912 @default.
- W2161883289 cites W2033766977 @default.
- W2161883289 cites W2034970968 @default.
- W2161883289 cites W2035254249 @default.
- W2161883289 cites W2035299250 @default.
- W2161883289 cites W2039212875 @default.
- W2161883289 cites W2039416798 @default.
- W2161883289 cites W2041295252 @default.
- W2161883289 cites W2041668589 @default.
- W2161883289 cites W2042143258 @default.
- W2161883289 cites W2042325710 @default.
- W2161883289 cites W2045317650 @default.
- W2161883289 cites W2045796751 @default.
- W2161883289 cites W2047270792 @default.
- W2161883289 cites W2051213045 @default.