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- W2161887310 abstract "Heart failure occurs in 2 - 3% of the adult population in the developed world. With decompensation of cardiac function, haemodynamic stability can be achieved by using intravenous vasodilators, diuretics and inotropes. Unlike traditional inotropes, Ca2+ sensitisers enhance cardiac function without significantly increasing cardiac oxygen consumption, promoting arrhythmia or impairing lusitropy. The most promising drug in this new class is levosimendan, which has a unique dual mechanism; it enhances cardiac output through a Ca(2+)-dependent stabilisation of cardiac myofilaments and exhibits vasodilatory effects by opening ATP-dependent K(+) channels. Clinical trials have demonstrated the beneficial haemodynamic effects of levosimendan, and prospective trials are currently underway to confirm its potential benefits on long-term prognosis. Updated guidelines from the European Society of Cardiology advise on how to incorporate levosimendan into care for patients who have acute heart failure." @default.
- W2161887310 created "2016-06-24" @default.
- W2161887310 creator A5016631318 @default.
- W2161887310 date "2005-06-01" @default.
- W2161887310 modified "2023-10-16" @default.
- W2161887310 title "An emerging role for calcium sensitisation in the treatment of heart failure" @default.
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- W2161887310 doi "https://doi.org/10.1517/13543784.14.6.659" @default.
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