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• W2161911625 abstract "ABSTRACT Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent host, but remains a major cause of morbidity in immunosuppressed individuals. Using the recently described technique of staining antigen-specific CD8 + T cells with peptide-HLA tetrameric complexes, we have demonstrated high levels of antigen-specific cells specific for HCMV peptides and show that this may exceed 4% of CD8 + T cells in immunocompetent donors. Moreover, by staining with tetramers in combination with antibodies to cell surface markers and intracellular cytokines, we demonstrate functional heterogeneity of HCMV-specific populations. A substantial proportion of these are effector cytotoxic T lymphocytes, as demonstrated by their ability to lyse peptide-pulsed targets in “fresh” killing assays. These data suggest that the immune response to HCMV is periodically boosted by a low level of HCMV replication and that sustained immunological surveillance contributes to the maintenance of host-pathogen homeostasis. These observations should improve our understanding of the immunobiology of persistent viral infection." @default.
• W2161911625 created "2016-06-24" @default.
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• W2161911625 date "2000-09-01" @default.
• W2161911625 modified "2023-10-17" @default.
• W2161911625 title "Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8⁺T Lymphocytes in Healthy Seropositive Donors" @default.
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• W2161911625 doi "https://doi.org/10.1128/jvi.74.17.8140-8150.2000" @default.
• W2161911625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/112348" @default.
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