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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161913484> ?p ?o ?g. }

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• W2161913484 abstract "We designed and synthesized polyhydroxylated pyrrolidines 1-12 from L-tyrosine, L-phenylalanine, and D-tyrosine through iodine-mediated intramolecular cyclization followed by Woodward-Prevost reaction. The synthetic polyhydroxylated pyrrolidines were identified with structure-based inhibitory activity and selective inhibitory activity against alpha-rhamnosidase. (2S,3S,4R)-deacetyl anisomycin 7 was the best inhibitor among the 12 polyhydroxylated pyrrolidines because it possesses the same stereoconfiguration at C1, C2, C3 as alpha-L-rhamnopyranoside. An investigation into the nature of the inhibition showed that the synthetic pyrrolidines are competitive inhibitors. They also did not have remarkable inhibitory activity against seven glycosidases (alpha-glucosidase, alpha-mannosidase, alpha-amylase, beta-glucosidase, beta-galactosidase, beta-amylase, and invertase)." @default.
• W2161913484 created "2016-06-24" @default.
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• W2161913484 date "2005-10-01" @default.
• W2161913484 modified "2023-09-25" @default.
• W2161913484 title "α-Rhamnosidase inhibitory activities of polyhydroxylated pyrrolidine" @default.
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• W2161913484 doi "https://doi.org/10.1016/j.bmcl.2005.06.051" @default.
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