FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161922332> ?p ?o ?g. }

• W2161922332 endingPage "42" @default.
• W2161922332 startingPage "34" @default.
• W2161922332 abstract "Cyclosporine A (CSA, calcineurin inhibitor) has been shown to block both vascular smooth muscle cell (VSMC) proliferation in cell culture and vessel neointimal formation following injury in vivo. The purpose of this study was to determine molecular and pathological effects of CSA on VSMCs. Using real-time reverse transcription-polymerase chain reaction, Western blot analysis, and immunofluorescence microscopy, we show that CSA up-regulated the expression of Krüppel-like factor-4 (KLF4) in VSMCs. KLF4 plays a key role in regulating VSMC phenotypic modulation. KLF4 antagonizes proliferation, facilitates migration, and down-regulates VSMC differentiation marker gene expression. We show that the VSMC differentiation marker genes smooth muscle alpha-actin (ACTA2), transgelin (TAGLN), smoothelin (SMTN), and myocardin (MYOCD) are all down-regulated by CSA in VSMC monoculture, whereas cyclin-dependent kinase inhibitor-1A (CDKN1A) and matrix metalloproteinase-3 (MMP3) are up-regulated. CSA did not affect the abundance of the VSMC microRNA (MIR) markers MIR143 and MIR145. Administration of CSA to rat carotid artery in vivo resulted in acute and transient suppression of ACTA2, TAGLN, SMTN, MYOCD, and smooth muscle myosin heavy chain (MYH11) mRNA levels. The tumor suppressor genes KLF4, p53, and CDKN1A, however, were up-regulated, as well as MMP3, MMP9, and collagen-VIII. CSA-treated arteries showed remarkable remodeling, including breakdown of the internal elastic lamina and reorientation of VSMCs, as well as increased KLF4 immunostaining in VSMCs and endothelial cells. Altogether, these data show that cyclosporin up-regulates KLF4 expression and promotes phenotypic modulation of VSMCs." @default.
• W2161922332 created "2016-06-24" @default.
• W2161922332 creator A5009931263 @default.
• W2161922332 creator A5042524683 @default.
• W2161922332 creator A5056729984 @default.
• W2161922332 creator A5076709710 @default.
• W2161922332 date "2010-01-20" @default.
• W2161922332 modified "2023-09-27" @default.
• W2161922332 title "Cyclosporine Up-Regulates Krüppel-Like Factor-4 (KLF4) in Vascular Smooth Muscle Cells and Drives Phenotypic Modulation In Vivo" @default.
• W2161922332 cites W1624803461 @default.
• W2161922332 cites W1912592877 @default.
• W2161922332 cites W1920479129 @default.
• W2161922332 cites W1976527906 @default.
• W2161922332 cites W1988277042 @default.
• W2161922332 cites W1994893847 @default.
• W2161922332 cites W1998179705 @default.
• W2161922332 cites W2005889517 @default.
• W2161922332 cites W2019222060 @default.
• W2161922332 cites W2022475385 @default.
• W2161922332 cites W2023833156 @default.
• W2161922332 cites W2029953646 @default.
• W2161922332 cites W2030036124 @default.
• W2161922332 cites W2042824681 @default.
• W2161922332 cites W2044762564 @default.
• W2161922332 cites W2048085771 @default.
• W2161922332 cites W2051598816 @default.
• W2161922332 cites W2053132428 @default.
• W2161922332 cites W2056728969 @default.
• W2161922332 cites W2057990672 @default.
• W2161922332 cites W2064323791 @default.
• W2161922332 cites W2067561562 @default.
• W2161922332 cites W2070114011 @default.
• W2161922332 cites W2090372317 @default.
• W2161922332 cites W2108661174 @default.
• W2161922332 cites W2114808160 @default.
• W2161922332 cites W2115528904 @default.
• W2161922332 cites W2121822802 @default.
• W2161922332 cites W2125760322 @default.
• W2161922332 cites W2125987139 @default.
• W2161922332 cites W2127956823 @default.
• W2161922332 cites W2128622802 @default.
• W2161922332 cites W2130489491 @default.
• W2161922332 cites W2132325104 @default.
• W2161922332 cites W2135281145 @default.
• W2161922332 cites W2139397108 @default.
• W2161922332 cites W2143689100 @default.
• W2161922332 cites W2146713119 @default.
• W2161922332 cites W2153341964 @default.
• W2161922332 cites W2154889368 @default.
• W2161922332 cites W2155062899 @default.
• W2161922332 cites W2156935469 @default.
• W2161922332 cites W2166169086 @default.
• W2161922332 cites W2168375312 @default.
• W2161922332 cites W2172082373 @default.
• W2161922332 cites W4256475235 @default.
• W2161922332 doi "https://doi.org/10.1124/jpet.109.163949" @default.
• W2161922332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2846029" @default.
• W2161922332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20089806" @default.
• W2161922332 hasPublicationYear "2010" @default.
• W2161922332 type Work @default.
• W2161922332 sameAs 2161922332 @default.
• W2161922332 citedByCount "44" @default.
• W2161922332 countsByYear W21619223322012 @default.
• W2161922332 countsByYear W21619223322013 @default.
• W2161922332 countsByYear W21619223322014 @default.
• W2161922332 countsByYear W21619223322015 @default.
• W2161922332 countsByYear W21619223322016 @default.
• W2161922332 countsByYear W21619223322017 @default.
• W2161922332 countsByYear W21619223322018 @default.
• W2161922332 countsByYear W21619223322019 @default.
• W2161922332 countsByYear W21619223322020 @default.
• W2161922332 countsByYear W21619223322021 @default.
• W2161922332 countsByYear W21619223322022 @default.
• W2161922332 countsByYear W21619223322023 @default.
• W2161922332 crossrefType "journal-article" @default.
• W2161922332 hasAuthorship W2161922332A5009931263 @default.
• W2161922332 hasAuthorship W2161922332A5042524683 @default.
• W2161922332 hasAuthorship W2161922332A5056729984 @default.
• W2161922332 hasAuthorship W2161922332A5076709710 @default.
• W2161922332 hasBestOaLocation W21619223322 @default.
• W2161922332 hasConcept C104317684 @default.
• W2161922332 hasConcept C125705527 @default.
• W2161922332 hasConcept C134018914 @default.
• W2161922332 hasConcept C150194340 @default.
• W2161922332 hasConcept C153911025 @default.
• W2161922332 hasConcept C2777933648 @default.
• W2161922332 hasConcept C2778265714 @default.
• W2161922332 hasConcept C2779395532 @default.
• W2161922332 hasConcept C2780286377 @default.
• W2161922332 hasConcept C2781011225 @default.
• W2161922332 hasConcept C2781122658 @default.
• W2161922332 hasConcept C2992686903 @default.
• W2161922332 hasConcept C502942594 @default.
• W2161922332 hasConcept C55493867 @default.
• W2161922332 hasConcept C69053785 @default.
• W2161922332 hasConcept C86339819 @default.
• W2161922332 hasConcept C86803240 @default.
• W2161922332 hasConcept C95444343 @default.

• next