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- W2161925909 abstract "One of the mechanism actions of antimalarial drugsi s by an inhibiting on the enzyme dihydrofolate redu ctase (DHFR), an enzyme target antifolate drug. Epi-croom ine and croomine , are alkaloids isolated from Stemonatuberosa showed DHFR inhibition with K i of 61.14 and 100.59 µM and K M values of30.68 and 27.06 µM at 10 ppm. The IC 50 to the DHFR of croomine and pyrimethamine were 5.2 9 and 7.71 µM, respectively. Tuberostemonine is not active to the enzyme. The ki netic analysis showed that both epi-croomine and cr oomine competitively inhibited to the human DHFR recombina nt. The molecular modeling of the compounds to the human DHFR was estimate depi-croomine and croomine’s bind ing free energy of -6.66 and -7.60 kcal/mol. The do cking showed that both epi-croomine and croomine could po ssibly form hydrogen bonds with the amino acid resi due of theAla9, which residues on the active site of the e nzyme." @default.
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- W2161925909 date "2014-01-01" @default.
- W2161925909 modified "2023-09-23" @default.
- W2161925909 title "Epi -croomine and croomine from Stemona tuberosa antimalarial drug for inhibiting dihydrofolate reductase (DHFR) activity and their molecular modeling" @default.
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