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- W2161937601 abstract "Conventional strategies of gene therapy using viral vectors result in suboptimal localization and potentially dangerous distal spread of vector. We hypothesized that site-specific delivery of adenoviral gene vectors could be achieved from a polyurethane (PU) film through a mechanism involving anti-viral antibody tethering. PU films were formulated with a collagen coating. Anti-adenoviral monoclonal antibodies were covalently bound to the collagen surface. These antibodies enabled tethering of replication defective adenoviruses through highly specific antigen-antibody affinity. We report for the first time successful PU filmbased gene delivery using antibody-tethered adenovirus encoding green fluorescent protein (GFP), demonstrating efficient and highly localized gene delivery to arterial smooth muscle cells in cell culture. We conclude that PU film is a suitable platform for a localizable viral vector delivery system that also prevents systemic spread of vector. Gene delivery using PU film-based anti-viral antibody tethering of vectors should be suitable for a wide array of single or multiple therapeutic gene strategies, and for further stent-based gene delivery therapeutic strategies." @default.
- W2161937601 created "2016-06-24" @default.
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- W2161937601 date "2005-01-01" @default.
- W2161937601 modified "2023-09-26" @default.
- W2161937601 title "Immobilization of gene vector on polyurethane surface using monoclonal antibody for site-specific gene therapy" @default.
- W2161937601 cites W2321167713 @default.
- W2161937601 doi "https://doi.org/10.1109/iembs.2005.1615363" @default.
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