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• W2161953204 abstract "We report a case of B-cell acute lymphocytic leukemia which showed histological transformation from an FAB-L2 into a Burkitt's type (FAB-L3). Both leukemias had identical immunoglobulin heavy-chain joining gene and kappa light-chain joining gene rearrangements, indicating the clonal identity of the two leukemias. A chromosomal analysis of leukemia cells on the onset indicated normal karyotype, whereas that of the transformed FAB-L3 showed t(8;14) (q24;q32). Furthermore, the proto-oncogene c-myc was in the germline configuration in the initial leukemia but in the rearranged configuration after transformation. Presence of t(8;14) (q24;q32) and the c-myc gene rearrangement after transformation suggested that the chromosomal translocation followed by the activation of the c-myc proto-oncogene might be involved in the Burkitt's type transformation of the FAB-L2 leukemic clone, but not in the leukemogenesis of the initial FAB-L2 leukemia." @default.
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• W2161953204 date "1997-01-01" @default.
• W2161953204 modified "2023-10-16" @default.
• W2161953204 title "A Translocation t(8;14) andc-mycGene Rearrangement Associated with the Histological Transformation of B-cell Acute Lymphocytic Leukemia (FAB-L2) into Burkitt's Type (FAB-L3) Leukemia" @default.
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• W2161953204 doi "https://doi.org/10.3109/10428199709059691" @default.
• W2161953204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9402334" @default.
• W2161953204 hasPublicationYear "1997" @default.
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