Matches in SemOpenAlex for { <https://semopenalex.org/work/W2161960954> ?p ?o ?g. }
- W2161960954 endingPage "342" @default.
- W2161960954 startingPage "335" @default.
- W2161960954 abstract "Female reproductive tract (FRT) epithelial cells protect against potential pathogens and sexually transmitted infections. The purpose of this study was to determine if epithelial cells from the upper FRT secrete antimicrobials that inhibit reproductive tract pathogens that threaten women's health. Apical secretions from primary cultures of Fallopian tube, uterine, cervical, and ectocervical epithelial cells were incubated with Neisseria gonorrhoeae, Candida albicans (yeast and hyphal forms), human immunodeficiency virus 1 (HIV-1), and Lactobacillus crispatus before being tested for their ability to grow and/or infect target cells. Epithelial cell secretions from the upper FRT inhibit N. gonorrhoeae and both forms of Candida, as well as reduce HIV-1 (R5) infection of target cells. In contrast, none had an inhibitory effect on L. crispatus. An analysis of cytokines and chemokines in uterine secretions revealed several molecules that could account for pathogen inhibition. These findings provide definitive evidence for the critical role of epithelial cells in protecting the FRT from infections, without comprising the beneficial presence of L. crispatus, which is part of the normal vaginal microflora of humans." @default.
- W2161960954 created "2016-06-24" @default.
- W2161960954 creator A5001976908 @default.
- W2161960954 creator A5003641722 @default.
- W2161960954 creator A5004346083 @default.
- W2161960954 creator A5008585229 @default.
- W2161960954 creator A5010077122 @default.
- W2161960954 creator A5015152228 @default.
- W2161960954 creator A5061094934 @default.
- W2161960954 creator A5063387479 @default.
- W2161960954 creator A5070687852 @default.
- W2161960954 date "2011-05-01" @default.
- W2161960954 modified "2023-10-10" @default.
- W2161960954 title "Epithelial cell secretions from the human female reproductive tract inhibit sexually transmitted pathogens and Candida albicans but not Lactobacillus" @default.
- W2161960954 cites W1489733175 @default.
- W2161960954 cites W1589692813 @default.
- W2161960954 cites W1628777611 @default.
- W2161960954 cites W1787801518 @default.
- W2161960954 cites W1948588917 @default.
- W2161960954 cites W1959149464 @default.
- W2161960954 cites W1963984954 @default.
- W2161960954 cites W1965485473 @default.
- W2161960954 cites W1968444539 @default.
- W2161960954 cites W1982034461 @default.
- W2161960954 cites W1984811742 @default.
- W2161960954 cites W1985754626 @default.
- W2161960954 cites W1988734740 @default.
- W2161960954 cites W1990798154 @default.
- W2161960954 cites W1992582986 @default.
- W2161960954 cites W2010213320 @default.
- W2161960954 cites W2025837117 @default.
- W2161960954 cites W2028110266 @default.
- W2161960954 cites W2030642888 @default.
- W2161960954 cites W2030971392 @default.
- W2161960954 cites W2039065953 @default.
- W2161960954 cites W2042704857 @default.
- W2161960954 cites W2043104844 @default.
- W2161960954 cites W2044776881 @default.
- W2161960954 cites W2048254575 @default.
- W2161960954 cites W2049934524 @default.
- W2161960954 cites W2053592784 @default.
- W2161960954 cites W2055295979 @default.
- W2161960954 cites W2057023184 @default.
- W2161960954 cites W2057198053 @default.
- W2161960954 cites W2065672519 @default.
- W2161960954 cites W2070149147 @default.
- W2161960954 cites W2076513631 @default.
- W2161960954 cites W2078988330 @default.
- W2161960954 cites W2082173481 @default.
- W2161960954 cites W2102329972 @default.
- W2161960954 cites W2103911193 @default.
- W2161960954 cites W2103940256 @default.
- W2161960954 cites W2106238870 @default.
- W2161960954 cites W2112712516 @default.
- W2161960954 cites W2113386659 @default.
- W2161960954 cites W2113646062 @default.
- W2161960954 cites W2116628722 @default.
- W2161960954 cites W2125377453 @default.
- W2161960954 cites W2143935360 @default.
- W2161960954 cites W2150075152 @default.
- W2161960954 cites W2151456025 @default.
- W2161960954 cites W2158401991 @default.
- W2161960954 cites W2159260794 @default.
- W2161960954 cites W2160892965 @default.
- W2161960954 cites W2165572249 @default.
- W2161960954 cites W4211190410 @default.
- W2161960954 doi "https://doi.org/10.1038/mi.2010.72" @default.
- W2161960954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3094926" @default.
- W2161960954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21048705" @default.
- W2161960954 hasPublicationYear "2011" @default.
- W2161960954 type Work @default.
- W2161960954 sameAs 2161960954 @default.
- W2161960954 citedByCount "62" @default.
- W2161960954 countsByYear W21619609542012 @default.
- W2161960954 countsByYear W21619609542013 @default.
- W2161960954 countsByYear W21619609542014 @default.
- W2161960954 countsByYear W21619609542015 @default.
- W2161960954 countsByYear W21619609542016 @default.
- W2161960954 countsByYear W21619609542017 @default.
- W2161960954 countsByYear W21619609542018 @default.
- W2161960954 countsByYear W21619609542019 @default.
- W2161960954 countsByYear W21619609542020 @default.
- W2161960954 countsByYear W21619609542021 @default.
- W2161960954 countsByYear W21619609542022 @default.
- W2161960954 countsByYear W21619609542023 @default.
- W2161960954 crossrefType "journal-article" @default.
- W2161960954 hasAuthorship W2161960954A5001976908 @default.
- W2161960954 hasAuthorship W2161960954A5003641722 @default.
- W2161960954 hasAuthorship W2161960954A5004346083 @default.
- W2161960954 hasAuthorship W2161960954A5008585229 @default.
- W2161960954 hasAuthorship W2161960954A5010077122 @default.
- W2161960954 hasAuthorship W2161960954A5015152228 @default.
- W2161960954 hasAuthorship W2161960954A5061094934 @default.
- W2161960954 hasAuthorship W2161960954A5063387479 @default.
- W2161960954 hasAuthorship W2161960954A5070687852 @default.
- W2161960954 hasBestOaLocation W21619609541 @default.
- W2161960954 hasConcept C13373296 @default.
- W2161960954 hasConcept C145081991 @default.