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• W2161972502 abstract "Non-motor symptoms of Parkinson's disease (PD) represent major causes of morbidity. RECOVER, a randomized controlled trial of rotigotine transdermal system, was the first prospective controlled trial to use the Non-Motor Symptoms Scale (NMSS) as an exploratory outcome for assessment of treatment effects on non-motor symptoms in PD. Rotigotine improved NMSS total score compared with placebo, and the Sleep/fatigue and Mood/apathy domains. This post hoc analysis further characterizes the effects of rotigotine on sleep/fatigue and mood/apathy.Patients with PD and unsatisfactory early-morning motor impairment were randomized to transdermal patches of rotigotine (2-16 mg/24 h) or placebo. Treatment was titrated to optimal dose over 1-8 weeks, maintained for 4 weeks. The NMSS was assessed at baseline and end of treatment. Post hoc analyses are presented for individual items of the Sleep/fatigue and Mood/apathy domains. The interpretation of p-values is considered exploratory in nature.Of 287 patients randomized, NMSS data were available for 267 patients (178 rotigotine, 89 placebo). Within the Sleep/fatigue domain there was a significant difference, in favor of rotigotine, in change from baseline score in 1 of 5 items: fatigue (tiredness) or lack of energy (ANCOVA, p < 0.0001). Within the Mood/apathy domain, there were significant differences in favor of rotigotine in 4 of 7 items: lost interest in surroundings (p < 0.0001), lost interest in doing things (p < 0.0001), seems sad or depressed (p < 0.01), and difficulty experiencing pleasure (p < 0.05).Rotigotine transdermal system may improve non-motor symptoms such as fatigue, symptoms of depression, anhedonia, and apathy in patients with PD; further prospective controlled studies are required to confirm this post hoc analysis." @default.
• W2161972502 created "2016-06-24" @default.
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• W2161972502 date "2013-07-01" @default.
• W2161972502 modified "2023-10-18" @default.
• W2161972502 title "Rotigotine and specific non-motor symptoms of Parkinson's disease: Post hoc analysis of RECOVER" @default.
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• W2161972502 doi "https://doi.org/10.1016/j.parkreldis.2013.02.018" @default.
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