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• W2161992291 endingPage "194" @default.
• W2161992291 startingPage "175" @default.
• W2161992291 abstract "Intracellular pathways related to cell survival regulate neuronal physiology during development and neurodegenerative disorders. One of the pathways that have recently emerged with an important role in these processes is nuclear factor-κB (NF-κB). The activity of this pathway leads to the nuclear translocation of the NF-κB transcription factors and the regulation of anti-apoptotic gene expression. Different stimuli can activate the pathway through different intracellular cascades (canonical, non-canonical, and atypical), contributing to the translocation of specific dimers of the NF-κB transcription factors, and each of these dimers can regulate the transcription of different genes. Recent studies have shown that the activation of this pathway regulates opposite responses such as cell survival or neuronal degeneration. These apparent contradictory effects depend on conditions such as the pathway stimuli, the origin of the cells, or the cellular context. In the present review, the authors summarize these findings and discuss their significance with respect to survival or death in the nervous system." @default.
• W2161992291 created "2016-06-24" @default.
• W2161992291 creator A5014126774 @default.
• W2161992291 creator A5087005928 @default.
• W2161992291 date "2012-07-10" @default.
• W2161992291 modified "2023-10-10" @default.
• W2161992291 title "NF-κB Signaling Pathways" @default.
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