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- W2161994839 abstract "Background. Immunity to chlamydia is thought to rely on interferon (IFN)-γ-secreting T helper cells type 1 (Th1) with an additional effect of secreted antibodies. A need for Th1-polarizing adjuvants in experimental chlamydia vaccines has been demonstrated, and antigen conformation has also been reported as being important for raising protective immunity. Methods. C57BL/6 mice vaccinated with native refolded Chlamydia muridarum major outer membrane protein (MOMP) adjuvanted with either Th1-promoting cationic adjuvant formulation 1 (CAF01) or T helper cells type 2-promoting aluminum hydroxide (alum) received a genital inoculation of 1.5 × 105 inclusion-forming units of C. muridarum. The role played by CD4+ T cells in MOMP/CAF01-raised immunity was investigated by depleting CD4+ T cells in vaccinated mice, and antigen conformation dependence was evaluated by vaccination with recombinant MOMP. Results. Mice vaccinated with MOMP/alum displayed a strong anti-MOMP humoral response with high IgG1 titers, low levels of IFN-γ and tumor necrosis factor (TNF)-α, and only a slight reduction in chlamydial load. Mice vaccinated with MOMP/CAF01 displayed high titers of IgG2b, IFN-γ, and TNF-α and a profoundly reduced vaginal chlamydial load, compared with control mice. The protection was CD4+ T cell dependent and was not dependent on MOMP conformation. Conclusion. CAF01 adjuvant facilitates a protective anti-MOMP CD4+ T cell response independent of MOMP conformation." @default.
- W2161994839 created "2016-06-24" @default.
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- W2161994839 date "2008-09-01" @default.
- W2161994839 modified "2023-09-25" @default.
- W2161994839 title "Liposome Delivery of<i>Chlamydia muridarum</i>Major Outer Membrane Protein Primes a Th1 Response That Protects against Genital Chlamydial Infection in a Mouse Model1" @default.
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- W2161994839 doi "https://doi.org/10.1086/590670" @default.
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