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- W2162000277 abstract "The diverse cell types and the precise synaptic connectivity between them are the cardinal features of the nervous system. Little is known about how cell fate diversification is linked to synaptic target choices. Here we investigate how presynaptic neurons select one type of muscles, vm2, as a synaptic target and form synapses on its dendritic spine-like muscle arms. We found that the Notch-Delta pathway was required to distinguish target from non-target muscles. APX-1/Delta acts in surrounding cells including the non-target vm1 to activate LIN-12/Notch in the target vm2. LIN-12 functions cell-autonomously to up-regulate the expression of UNC-40/DCC and MADD-2 in vm2, which in turn function together to promote muscle arm formation and guidance. Ectopic expression of UNC-40/DCC in non-target vm1 muscle is sufficient to induce muscle arm extension from these cells. Therefore, the LIN-12/Notch signaling specifies target selection by selectively up-regulating guidance molecules and forming muscle arms in target cells." @default.
- W2162000277 created "2016-06-24" @default.
- W2162000277 creator A5011774992 @default.
- W2162000277 creator A5034690690 @default.
- W2162000277 creator A5050231499 @default.
- W2162000277 creator A5067304730 @default.
- W2162000277 date "2013-03-19" @default.
- W2162000277 modified "2023-10-17" @default.
- W2162000277 title "LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans" @default.
- W2162000277 cites W1554209941 @default.
- W2162000277 cites W1592915406 @default.
- W2162000277 cites W1612484725 @default.
- W2162000277 cites W1790499166 @default.
- W2162000277 cites W1968343429 @default.
- W2162000277 cites W1970489875 @default.
- W2162000277 cites W1971291306 @default.
- W2162000277 cites W1972706019 @default.
- W2162000277 cites W1976179891 @default.
- W2162000277 cites W1980258223 @default.
- W2162000277 cites W1984059331 @default.
- W2162000277 cites W1985657116 @default.
- W2162000277 cites W1985784930 @default.
- W2162000277 cites W1993490391 @default.
- W2162000277 cites W1998671806 @default.
- W2162000277 cites W2003398390 @default.
- W2162000277 cites W2004689860 @default.
- W2162000277 cites W2004940993 @default.
- W2162000277 cites W2006229889 @default.
- W2162000277 cites W2006996147 @default.
- W2162000277 cites W2012782842 @default.
- W2162000277 cites W2017702115 @default.
- W2162000277 cites W2018697745 @default.
- W2162000277 cites W2019399041 @default.
- W2162000277 cites W2021515035 @default.
- W2162000277 cites W2024732305 @default.
- W2162000277 cites W2026962070 @default.
- W2162000277 cites W2028916975 @default.
- W2162000277 cites W2031599833 @default.
- W2162000277 cites W2032367884 @default.
- W2162000277 cites W2033477896 @default.
- W2162000277 cites W2037103320 @default.
- W2162000277 cites W2040848874 @default.
- W2162000277 cites W2041338073 @default.
- W2162000277 cites W2044583800 @default.
- W2162000277 cites W2046544898 @default.
- W2162000277 cites W2046968637 @default.
- W2162000277 cites W2052133788 @default.
- W2162000277 cites W2053093866 @default.
- W2162000277 cites W2057364898 @default.
- W2162000277 cites W2058202542 @default.
- W2162000277 cites W2059752598 @default.
- W2162000277 cites W2063365688 @default.
- W2162000277 cites W2063962655 @default.
- W2162000277 cites W2064580246 @default.
- W2162000277 cites W2066844640 @default.
- W2162000277 cites W2067561211 @default.
- W2162000277 cites W2068995326 @default.
- W2162000277 cites W2074557008 @default.
- W2162000277 cites W2076450052 @default.
- W2162000277 cites W2079458003 @default.
- W2162000277 cites W2081235375 @default.
- W2162000277 cites W2081545668 @default.
- W2162000277 cites W2081733923 @default.
- W2162000277 cites W2083177518 @default.
- W2162000277 cites W2083425643 @default.
- W2162000277 cites W2083947555 @default.
- W2162000277 cites W2090865074 @default.
- W2162000277 cites W2091056760 @default.
- W2162000277 cites W2092830701 @default.
- W2162000277 cites W2093476069 @default.
- W2162000277 cites W2100100832 @default.
- W2162000277 cites W2107649324 @default.
- W2162000277 cites W2108080306 @default.
- W2162000277 cites W2109791816 @default.
- W2162000277 cites W2114604503 @default.
- W2162000277 cites W2122458935 @default.
- W2162000277 cites W2123876128 @default.
- W2162000277 cites W2128625570 @default.
- W2162000277 cites W2129092300 @default.
- W2162000277 cites W2129420942 @default.
- W2162000277 cites W2133885516 @default.
- W2162000277 cites W2141752067 @default.
- W2162000277 cites W2143022663 @default.
- W2162000277 cites W2145294610 @default.
- W2162000277 cites W2148334975 @default.
- W2162000277 cites W2149519740 @default.
- W2162000277 cites W2153313664 @default.
- W2162000277 cites W2154675484 @default.
- W2162000277 cites W2155870242 @default.
- W2162000277 cites W2160938187 @default.
- W2162000277 cites W2164331820 @default.
- W2162000277 cites W2166087446 @default.
- W2162000277 cites W2166198383 @default.
- W2162000277 cites W2167582537 @default.
- W2162000277 cites W2168656510 @default.
- W2162000277 cites W2170443224 @default.
- W2162000277 cites W2184124501 @default.
- W2162000277 cites W2332539548 @default.
- W2162000277 cites W47559429 @default.
- W2162000277 cites W2044096728 @default.