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- W2162004147 abstract "Conflicts of interest: none declared. Sir, Interindividual variation in the metabolism of azathioprine, commonly used post‐transplant, can be due to the presence of genetic polymorphisms affecting the thiopurine S‐methyltransferase gene (TPMT).1 Standard dosing of azathioprine can expose patients with TPMT variants to a larger burden of immunosuppression over the duration of transplant.2 The aim of this retrospective study was to define the frequency and significance of TPMT nonfunctional mutations in a renal transplant population. This study was primarily carried out in Beaumont Hospital, the national renal transplant centre in Ireland. Additional patients were recruited from the Adelaide and Meath Hospital, Tallaght, Dublin. Ethical approval for this study was received. Patients older than 16 years of age were interviewed and examined by one observer (F.J.M.). Data were collected using a standardized questionnaire as previously described.3 Renal transplant recipients (RTR) with and without skin cancer were genotyped for TPMT*2 (G238C), TPMT*3A (G460A, A719G), TPMT*3B (G460A) and TPMT*3C (A719G). Genomic DNA was isolated from a peripheral venous blood sample and genotyping was performed using the AmplifluorTM method by K Biosciences (http://www.kbioscience.co.uk). Categorical variables were tested using χ2 and Mantel–Haenszel statistics while continuous variables were tested using Student's t‐test and Wilcoxon two‐sample test. In the analyses, older age, longer duration since transplantation, fairer skin type and higher total sun exposure score (P < 0·0001) were shown to be predictors of increased skin cancer risk. The association of TPMT variants with skin cancer risk was therefore initially tested using a Cochrane–Armitage trend test and adjusted odds ratios (ORs) were then calculated based on a logistic regression, factoring in the above covariates." @default.
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- W2162004147 date "2006-03-30" @default.
- W2162004147 modified "2023-09-27" @default.
- W2162004147 title "The frequency and significance of thiopurine <i>S</i> -methyltransferase gene polymorphisms in azathioprine-treated renal transplant recipients" @default.
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- W2162004147 doi "https://doi.org/10.1111/j.1365-2133.2006.07239.x" @default.
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