FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162048896> ?p ?o ?g. }

• W2162048896 endingPage "e86236" @default.
• W2162048896 startingPage "e86236" @default.
• W2162048896 abstract "Adrenal corticosteroid hormones act via mineralocorticoid (MR) and glucocorticoid receptors (GR) in the brain, influencing learning and memory. MRs have been implicated in the initial behavioral response in novel situations, which includes behavioral strategies in learning tasks. Different strategies can be used to solve navigational tasks, for example hippocampus-dependent spatial or striatum-dependent stimulus-response strategies. Previous studies suggested that MRs are involved in spatial learning and induce a shift between learning strategies when animals are allowed a choice between both strategies. In the present study, we further explored the role of MRs in spatial and stimulus-response learning in two separate circular holeboard tasks using female mice with forebrain-specific MR deficiency and MR overexpression and their wildtype control littermates. In addition, we studied sex-specific effects using male and female MR-deficient mice. First, we found that MR-deficient compared to control littermates and MR-overexpressing mice display altered exploratory and searching behavior indicative of impaired acquisition of novel information. Second, female (but not male) MR-deficient mice were impaired in the spatial task, while MR-overexpressing female mice showed improved performance in the spatial task. Third, MR-deficient mice were also impaired in the stimulus-response task compared to controls and (in the case of females) MR-overexpressing mice. We conclude that MRs are important for coordinating the processing of information relevant for spatial as well as stimulus-response learning." @default.
• W2162048896 created "2016-06-24" @default.
• W2162048896 creator A5026964082 @default.
• W2162048896 creator A5043048544 @default.
• W2162048896 creator A5059016448 @default.
• W2162048896 creator A5064429146 @default.
• W2162048896 creator A5069823044 @default.
• W2162048896 creator A5076449918 @default.
• W2162048896 creator A5086284254 @default.
• W2162048896 date "2014-01-21" @default.
• W2162048896 modified "2023-10-10" @default.
• W2162048896 title "Mineralocorticoid Receptors Guide Spatial and Stimulus-Response Learning in Mice" @default.
• W2162048896 cites W1635144889 @default.
• W2162048896 cites W1981361333 @default.
• W2162048896 cites W1983242030 @default.
• W2162048896 cites W1986381796 @default.
• W2162048896 cites W1989330193 @default.
• W2162048896 cites W1998476901 @default.
• W2162048896 cites W2008175050 @default.
• W2162048896 cites W2008290637 @default.
• W2162048896 cites W2008301967 @default.
• W2162048896 cites W2015670274 @default.
• W2162048896 cites W2024824460 @default.
• W2162048896 cites W2029404396 @default.
• W2162048896 cites W2032724628 @default.
• W2162048896 cites W2033132308 @default.
• W2162048896 cites W2044806898 @default.
• W2162048896 cites W2045104125 @default.
• W2162048896 cites W2045369517 @default.
• W2162048896 cites W2063884007 @default.
• W2162048896 cites W2071532085 @default.
• W2162048896 cites W2074802748 @default.
• W2162048896 cites W2076805718 @default.
• W2162048896 cites W2080692568 @default.
• W2162048896 cites W2088445784 @default.
• W2162048896 cites W2093400617 @default.
• W2162048896 cites W2094506715 @default.
• W2162048896 cites W2096240659 @default.
• W2162048896 cites W2097578495 @default.
• W2162048896 cites W2108460086 @default.
• W2162048896 cites W2111296546 @default.
• W2162048896 cites W2113690251 @default.
• W2162048896 cites W2114665617 @default.
• W2162048896 cites W2116629441 @default.
• W2162048896 cites W2122712485 @default.
• W2162048896 cites W2132043124 @default.
• W2162048896 cites W2142105761 @default.
• W2162048896 cites W2147895657 @default.
• W2162048896 cites W2148731425 @default.
• W2162048896 cites W2156945476 @default.
• W2162048896 cites W2158321995 @default.
• W2162048896 cites W2166623778 @default.
• W2162048896 cites W2169187342 @default.
• W2162048896 cites W2169479929 @default.
• W2162048896 cites W4237012674 @default.
• W2162048896 doi "https://doi.org/10.1371/journal.pone.0086236" @default.
• W2162048896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3897662" @default.
• W2162048896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24465979" @default.
• W2162048896 hasPublicationYear "2014" @default.
• W2162048896 type Work @default.
• W2162048896 sameAs 2162048896 @default.
• W2162048896 citedByCount "26" @default.
• W2162048896 countsByYear W21620488962014 @default.
• W2162048896 countsByYear W21620488962015 @default.
• W2162048896 countsByYear W21620488962016 @default.
• W2162048896 countsByYear W21620488962017 @default.
• W2162048896 countsByYear W21620488962019 @default.
• W2162048896 countsByYear W21620488962020 @default.
• W2162048896 countsByYear W21620488962021 @default.
• W2162048896 countsByYear W21620488962022 @default.
• W2162048896 countsByYear W21620488962023 @default.
• W2162048896 crossrefType "journal-article" @default.
• W2162048896 hasAuthorship W2162048896A5026964082 @default.
• W2162048896 hasAuthorship W2162048896A5043048544 @default.
• W2162048896 hasAuthorship W2162048896A5059016448 @default.
• W2162048896 hasAuthorship W2162048896A5064429146 @default.
• W2162048896 hasAuthorship W2162048896A5069823044 @default.
• W2162048896 hasAuthorship W2162048896A5076449918 @default.
• W2162048896 hasAuthorship W2162048896A5086284254 @default.
• W2162048896 hasBestOaLocation W21620488961 @default.
• W2162048896 hasConcept C126322002 @default.
• W2162048896 hasConcept C134018914 @default.
• W2162048896 hasConcept C15744967 @default.
• W2162048896 hasConcept C169760540 @default.
• W2162048896 hasConcept C170493617 @default.
• W2162048896 hasConcept C180747234 @default.
• W2162048896 hasConcept C189135053 @default.
• W2162048896 hasConcept C2776069600 @default.
• W2162048896 hasConcept C2779715522 @default.
• W2162048896 hasConcept C2779918689 @default.
• W2162048896 hasConcept C2780062018 @default.
• W2162048896 hasConcept C2780841215 @default.
• W2162048896 hasConcept C2781161787 @default.
• W2162048896 hasConcept C2985665543 @default.
• W2162048896 hasConcept C513476851 @default.
• W2162048896 hasConcept C529278444 @default.
• W2162048896 hasConcept C59493245 @default.
• W2162048896 hasConcept C71924100 @default.

• next