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• W2162079067 abstract "Different flavonoids are known to interfere with influenza A virus replication. Recently, we showed that the structurally similar flavonoids baicalein and biochanin A inhibit highly pathogenic avian H5N1 influenza A virus replication by different mechanisms in A549 lung cells. Here, we investigated the effects of both compounds on H5N1-induced reactive oxygen species (ROS) formation and the role of ROS formation during H5N1 replication. Baicalein and biochanin A enhanced H5N1-induced ROS formation in A549 cells and primary human monocyte-derived macrophages. Suppression of ROS formation induced by baicalein and biochanin A using the antioxidant N-acetyl-L-cysteine strongly increased the anti-H5N1 activity of both compounds in A549 cells but not in macrophages. These findings emphasise that flavonoids induce complex pharmacological actions some of which may interfere with H5N1 replication while others may support H5N1 replication. A more detailed understanding of these actions and the underlying structure-activity relationships is needed to design agents with optimised anti-H5N1 activity." @default.
• W2162079067 created "2016-06-24" @default.
• W2162079067 creator A5019350041 @default.
• W2162079067 creator A5058177040 @default.
• W2162079067 creator A5074740364 @default.
• W2162079067 date "2014-06-23" @default.
• W2162079067 modified "2023-10-09" @default.
• W2162079067 title "Effects of flavonoid-induced oxidative stress on anti-H5N1 influenza a virus activity exerted by baicalein and biochanin A" @default.
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• W2162079067 doi "https://doi.org/10.1186/1756-0500-7-384" @default.
• W2162079067 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4080993" @default.
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