FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162079087> ?p ?o ?g. }

• W2162079087 abstract "Parkinson's disease (PD) is the most common movement disorder. While neuronal deposition of alpha-synuclein serves as a pathological hallmark of PD and Dementia with Lewy Bodies, alpha-synuclein-positive protein aggregates are also present in astrocytes. The pathological consequence of astrocytic accumulation of alpha-synuclein, however, is unclear.Here we show that PD-related A53T mutant alpha-synuclein, when selectively expressed in astrocytes, induced rapidly progressed paralysis in mice. Increasing accumulation of alpha-synuclein aggregates was found in presymptomatic and symptomatic mouse brains and correlated with the expansion of reactive astrogliosis. The normal function of astrocytes was compromised as evidenced by cerebral microhemorrhage and down-regulation of astrocytic glutamate transporters, which also led to increased inflammatory responses and microglial activation. Interestingly, the activation of microglia was mainly detected in the midbrain, brainstem and spinal cord, where a significant loss of dopaminergic and motor neurons was observed. Consistent with the activation of microglia, the expression level of cyclooxygenase 1 (COX-1) was significantly up-regulated in the brain of symptomatic mice and in cultured microglia treated with conditioned medium derived from astrocytes over-expressing A53T alpha-synuclein. Consequently, the suppression of COX-1 activities extended the survival of mutant mice, suggesting that excess inflammatory responses elicited by reactive astrocytes may contribute to the degeneration of neurons.Our findings demonstrate a critical involvement of astrocytic alpha-synuclein in initiating the non-cell autonomous killing of neurons, suggesting the viability of reactive astrocytes and microglia as potential therapeutic targets for PD and other neurodegenerative diseases." @default.
• W2162079087 created "2016-06-24" @default.
• W2162079087 creator A5045641777 @default.
• W2162079087 creator A5046327313 @default.
• W2162079087 creator A5054853061 @default.
• W2162079087 creator A5057541775 @default.
• W2162079087 creator A5058165407 @default.
• W2162079087 creator A5084568979 @default.
• W2162079087 date "2010-04-21" @default.
• W2162079087 modified "2023-10-18" @default.
• W2162079087 title "Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice" @default.
• W2162079087 cites W1527671059 @default.
• W2162079087 cites W1564677510 @default.
• W2162079087 cites W1965111978 @default.
• W2162079087 cites W1965778124 @default.
• W2162079087 cites W1975774284 @default.
• W2162079087 cites W1977043703 @default.
• W2162079087 cites W1978525572 @default.
• W2162079087 cites W1980020952 @default.
• W2162079087 cites W1980110509 @default.
• W2162079087 cites W1986628169 @default.
• W2162079087 cites W1991805788 @default.
• W2162079087 cites W1992483894 @default.
• W2162079087 cites W1992758695 @default.
• W2162079087 cites W1996123970 @default.
• W2162079087 cites W1996943173 @default.
• W2162079087 cites W2003674452 @default.
• W2162079087 cites W2004349171 @default.
• W2162079087 cites W2011332000 @default.
• W2162079087 cites W2012108027 @default.
• W2162079087 cites W2015541518 @default.
• W2162079087 cites W2015951393 @default.
• W2162079087 cites W2017407647 @default.
• W2162079087 cites W2025922492 @default.
• W2162079087 cites W2031299209 @default.
• W2162079087 cites W2031982078 @default.
• W2162079087 cites W2033402586 @default.
• W2162079087 cites W2034283361 @default.
• W2162079087 cites W2039436205 @default.
• W2162079087 cites W2055750901 @default.
• W2162079087 cites W2056304112 @default.
• W2162079087 cites W2058409097 @default.
• W2162079087 cites W2059261643 @default.
• W2162079087 cites W2067102106 @default.
• W2162079087 cites W2068147651 @default.
• W2162079087 cites W2070953412 @default.
• W2162079087 cites W2076078146 @default.
• W2162079087 cites W2079320514 @default.
• W2162079087 cites W2088481573 @default.
• W2162079087 cites W2091265794 @default.
• W2162079087 cites W2091845372 @default.
• W2162079087 cites W2103444316 @default.
• W2162079087 cites W2116597539 @default.
• W2162079087 cites W2120412340 @default.
• W2162079087 cites W2121981334 @default.
• W2162079087 cites W2122113931 @default.
• W2162079087 cites W2123431154 @default.
• W2162079087 cites W2127376676 @default.
• W2162079087 cites W2146546145 @default.
• W2162079087 cites W2150656456 @default.
• W2162079087 cites W2153235303 @default.
• W2162079087 cites W2154737306 @default.
• W2162079087 cites W2155738133 @default.
• W2162079087 cites W2163311553 @default.
• W2162079087 cites W4296217171 @default.
• W2162079087 cites W82853573 @default.
• W2162079087 doi "https://doi.org/10.1186/1756-6606-3-12" @default.
• W2162079087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2873589" @default.
• W2162079087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20409326" @default.
• W2162079087 hasPublicationYear "2010" @default.
• W2162079087 type Work @default.
• W2162079087 sameAs 2162079087 @default.
• W2162079087 citedByCount "252" @default.
• W2162079087 countsByYear W21620790872012 @default.
• W2162079087 countsByYear W21620790872013 @default.
• W2162079087 countsByYear W21620790872014 @default.
• W2162079087 countsByYear W21620790872015 @default.
• W2162079087 countsByYear W21620790872016 @default.
• W2162079087 countsByYear W21620790872017 @default.
• W2162079087 countsByYear W21620790872018 @default.
• W2162079087 countsByYear W21620790872019 @default.
• W2162079087 countsByYear W21620790872020 @default.
• W2162079087 countsByYear W21620790872021 @default.
• W2162079087 countsByYear W21620790872022 @default.
• W2162079087 countsByYear W21620790872023 @default.
• W2162079087 crossrefType "journal-article" @default.
• W2162079087 hasAuthorship W2162079087A5045641777 @default.
• W2162079087 hasAuthorship W2162079087A5046327313 @default.
• W2162079087 hasAuthorship W2162079087A5054853061 @default.
• W2162079087 hasAuthorship W2162079087A5057541775 @default.
• W2162079087 hasAuthorship W2162079087A5058165407 @default.
• W2162079087 hasAuthorship W2162079087A5084568979 @default.
• W2162079087 hasBestOaLocation W21620790871 @default.
• W2162079087 hasConcept C137183658 @default.
• W2162079087 hasConcept C142724271 @default.
• W2162079087 hasConcept C169760540 @default.
• W2162079087 hasConcept C203014093 @default.
• W2162079087 hasConcept C2776914184 @default.
• W2162079087 hasConcept C2776925932 @default.
• W2162079087 hasConcept C2777542381 @default.

• next