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- W2162088045 abstract "Arsenite, the trivalent form of arsenic present in the environment, is a known human carcinogen that lacked mutagenic activity in bacterial and standard mammalian cell mutation assays. We show herein that when evaluated in an assay (A L cell assay), in which both intragenic and multilocus mutations are detectable, that arsenite is in fact a strong dose-dependent mutagen and that it induces mostly large deletion mutations. Cotreatment of cells with the oxygen radical scavenger dimethyl sulfoxide significantly reduces the mutagenicity of arsenite. Thus, the carcinogenicity of arsenite can be explained at least in part by it being a mutagen that depends on reactive oxygen species for its activity." @default.
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- W2162088045 date "1998-07-07" @default.
- W2162088045 modified "2023-10-09" @default.
- W2162088045 title "Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species" @default.
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- W2162088045 doi "https://doi.org/10.1073/pnas.95.14.8103" @default.
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