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• W2162099328 abstract "Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition of TE-13 cell proliferation. The promoter hypermethylation of RKIP was found to occur in dysplastic tissues and a close correlation was noted between RKIP methylation and the loss of mRNA and protein expression of the gene in ESCC specimens. In summary, RKIP may act as a tumor suppressor gene in esophageal cancer." @default.
• W2162099328 created "2016-06-24" @default.
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• W2162099328 date "2012-10-15" @default.
• W2162099328 modified "2023-10-04" @default.
• W2162099328 title "Decreased Expression and Aberrant Methylation of Raf Kinase Inhibitory Protein Gene in Esophageal Squamous Cell Carcinoma" @default.
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• W2162099328 doi "https://doi.org/10.3109/07357907.2012.732164" @default.
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