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• W2162144846 abstract "Objectives: The HER-2/neu oncogene is overexpressed in many types of cancer and especially in 25% to 30% of breast cancers. Single reports mention HER-2/neu positivity in hematological malignancies like Hodgkins's disease and even diffuse large-cell lymphoma. Objective. To test for HER-2/neu overexpression in patients with non- Hodgkin's lymphoma and the possible role of the recombinant monoclonal anti-HER-2/neu antibody trastuzumab (Herceptin ® ) in the treatment of non-Hodgkin's lymphoma. Materials and Methods: Serum samples from 87 consecutive unselected patients with non-Hodgkin's lymphoma were retrospectively retrieved from a serum bank and tested for the shed antigen of HER-2/neu using the Oncogene Science ® ELISA assay (Cambridge, MA, USA). From those lymphoma patients, the paraffin-embedded lymph-node specimens of 25 cases with diffuse large-cell lymphoma were stained with the HER-2/neu DAKO HercepTest ® . Results: In 87 lymphoma" @default.
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• W2162144846 date "2004-09-01" @default.
• W2162144846 modified "2023-09-24" @default.
• W2162144846 title "Lack of HER-2/neu Overexpression in Non-Hodgkin's Lymphoma" @default.
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• W2162144846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15510616" @default.
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